Time and dose effect of transdermal nicotine on endothelial function
Miller V, Clouse W, Tonnessen B, Boston U, Severson S, Bonde S, Rud K, Hurt R. Time and dose effect of transdermal nicotine on endothelial function. AJP Heart And Circulatory Physiology 2000, 279: h1913-h1921. PMID: 11009480, DOI: 10.1152/ajpheart.2000.279.4.h1913.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine DiphosphateAdministration, CutaneousAnimalsAortaCalcimycinCalciumCoronary VesselsCotinineDogsDose-Response Relationship, DrugEndothelium, VascularEnzyme InhibitorsIn Vitro TechniquesIonophoresMaleNicotineNitratesNitric Oxide SynthaseNitritesOmega-N-MethylarginineRNA, MessengerTime FactorsVasodilationConceptsEndothelium-dependent responsesEndothelium-dependent relaxationNicotine patchNicotine treatmentNitric oxideNicotine patch therapyEffects of nicotineBiphasic dose effectDose effectCalcium ionophore AAortic endothelial cellsTransdermal nicotineEndothelial functionPatch therapyCoronary arteryCounter medicationsCessation programsNOS activityAdrenergic agonistsNOS mRNAIonophore AIsometric forceEndothelial cellsNicotineDose range