Modulation of nitric-oxide synthase by nicotine.
Tonnessen B, Severson S, Hurt R, Miller V. Modulation of nitric-oxide synthase by nicotine. Journal Of Pharmacology And Experimental Therapeutics 2000, 295: 601-6. PMID: 11046094.Peer-Reviewed Original ResearchConceptsEndothelial nitric oxide synthaseRecombinant endothelial nitric oxide synthaseEffects of nicotineNitric oxide synthaseAortic endothelial cellsNitric oxideInducible NOSNeuronal NOSEndothelium-derived nitric oxideEndothelial cellsEndothelium-dependent relaxationCalcium-dependent accumulationPresence of nicotineUntreated dogsNicotine administrationM nicotineNOS activityNicotine doseNOSNicotineCitrulline accumulationInconsistent findingsConcentration of NADPHCitrullineAccumulation of citrullineTime and dose effect of transdermal nicotine on endothelial function
Miller V, Clouse W, Tonnessen B, Boston U, Severson S, Bonde S, Rud K, Hurt R. Time and dose effect of transdermal nicotine on endothelial function. AJP Heart And Circulatory Physiology 2000, 279: h1913-h1921. PMID: 11009480, DOI: 10.1152/ajpheart.2000.279.4.h1913.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine DiphosphateAdministration, CutaneousAnimalsAortaCalcimycinCalciumCoronary VesselsCotinineDogsDose-Response Relationship, DrugEndothelium, VascularEnzyme InhibitorsIn Vitro TechniquesIonophoresMaleNicotineNitratesNitric Oxide SynthaseNitritesOmega-N-MethylarginineRNA, MessengerTime FactorsVasodilationConceptsEndothelium-dependent responsesEndothelium-dependent relaxationNicotine patchNicotine treatmentNitric oxideNicotine patch therapyEffects of nicotineBiphasic dose effectDose effectCalcium ionophore AAortic endothelial cellsTransdermal nicotineEndothelial functionPatch therapyCoronary arteryCounter medicationsCessation programsNOS activityAdrenergic agonistsNOS mRNAIonophore AIsometric forceEndothelial cellsNicotineDose range