Modulation of nitric-oxide synthase by nicotine.
Tonnessen B, Severson S, Hurt R, Miller V. Modulation of nitric-oxide synthase by nicotine. Journal Of Pharmacology And Experimental Therapeutics 2000, 295: 601-6. PMID: 11046094.Peer-Reviewed Original ResearchConceptsEndothelial nitric oxide synthaseRecombinant endothelial nitric oxide synthaseEffects of nicotineNitric oxide synthaseAortic endothelial cellsNitric oxideInducible NOSNeuronal NOSEndothelium-derived nitric oxideEndothelial cellsEndothelium-dependent relaxationCalcium-dependent accumulationPresence of nicotineUntreated dogsNicotine administrationM nicotineNOS activityNicotine doseNOSNicotineCitrulline accumulationInconsistent findingsConcentration of NADPHCitrullineAccumulation of citrulline