2017
Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial of RG7667, a Combination Monoclonal Antibody, for Prevention of Cytomegalovirus Infection in High-Risk Kidney Transplant Recipients
Ishida JH, Patel A, Mehta AK, Gatault P, McBride JM, Burgess T, Derby MA, Snydman DR, Emu B, Feierbach B, Fouts AE, Maia M, Deng R, Rosenberger CM, Gennaro LA, Striano NS, Liao XC, Tavel JA. Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial of RG7667, a Combination Monoclonal Antibody, for Prevention of Cytomegalovirus Infection in High-Risk Kidney Transplant Recipients. Antimicrobial Agents And Chemotherapy 2017, 61: 10.1128/aac.01794-16. PMID: 27872061, PMCID: PMC5278717, DOI: 10.1128/aac.01794-16.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalCytomegalovirus InfectionsFemaleHumansKidney TransplantationMaleMiddle AgedPlacebosTreatment OutcomeViremiaConceptsHigh-risk kidney transplant recipientsKidney transplant recipientsCMV viremiaTransplant recipientsCMV diseaseCMV infectionCytomegalovirus infectionMonoclonal antibodiesCMV-seronegative recipientsCMV-seropositive donorsLess CMV diseasePlacebo-controlled trialTime of transplantKidney transplantationPlacebo groupAdverse eventsKidney transplantMedian timeSignificant complicationsPlaceboTreatment groupsPatientsViremiaInfectionWeeks
2007
Loss of T cell responses following long-term cryopreservation
Owen RE, Sinclair E, Emu B, Heitman JW, Hirschkorn DF, Epling CL, Tan QX, Custer B, Harris JM, Jacobson MA, McCune JM, Martin JN, Hecht FM, Deeks SG, Norris PJ. Loss of T cell responses following long-term cryopreservation. Journal Of Immunological Methods 2007, 326: 93-115. PMID: 17707394, PMCID: PMC2065759, DOI: 10.1016/j.jim.2007.07.012.Peer-Reviewed Original ResearchConceptsT cell IFN-gamma responsesT cell responsesHuman immunodeficiency virusIFN-gamma responsesPeripheral blood mononuclear cellsCell responsesLong-term cryopreservationPeptide poolsHIV-negative individualsBlood mononuclear cellsLoss of responseT cell apoptosisPhenotypic marker expressionDecrement of responseOvernight restingEffector cellsImmunodeficiency virusExogenous antigensMononuclear cellsShort-term cryopreservationHIV peptidesFuture vaccinesImpact of cryopreservationPathogenesis studiesMarker expression