Heme-induced genes facilitate endosymbiont (Sodalis glossinidius) colonization of the tsetse fly (Glossina morsitans) midgut
Runyen-Janecky L, Scheutzow J, Farsin R, Cabo L, Wall K, Kuhn K, Amador R, D’Souza S, Vigneron A, Weiss B. Heme-induced genes facilitate endosymbiont (Sodalis glossinidius) colonization of the tsetse fly (Glossina morsitans) midgut. PLOS Neglected Tropical Diseases 2022, 16: e0010833. PMID: 36441823, PMCID: PMC9731421, DOI: 10.1371/journal.pntd.0010833.Peer-Reviewed Original ResearchConceptsTsetse midgutHeme environmentDNA-binding proteinsGene Ontology termsBlood mealTsetse fly midgutVertebrate bloodBacterial genesHost midgutOntology termsDisease-causing pathogensBiological functionsGene expressionMutant strainFucose transporterInsertion mutationsMetabolic processesHost competencyEnvironmental stressorsFly midgutMidgutGenesSodalisTsetse fliesHeme