1995
Blockade of C5a and C5b-9 generation inhibits leukocyte and platelet activation during extracorporeal circulation.
Rinder CS, Rinder HM, Smith BR, Fitch JC, Smith MJ, Tracey JB, Matis LA, Squinto SP, Rollins SA. Blockade of C5a and C5b-9 generation inhibits leukocyte and platelet activation during extracorporeal circulation. Journal Of Clinical Investigation 1995, 96: 1564-1572. PMID: 7657827, PMCID: PMC185782, DOI: 10.1172/jci118195.Peer-Reviewed Original ResearchConceptsCardiopulmonary bypassExtracorporeal circulationSerum complement hemolytic activityComplement activationComplement componentsP-selectin-positive plateletsC5 complement componentNeutrophil CD11b upregulationSystemic inflammatory responseBlockade of C5aComplement hemolytic activityC5b-9 generationNeutrophil activationCD11b upregulationControl MAbInflammatory responseTherapeutic interventionsPlatelet activationCellular activationC5b-9BypassC5aC3a generationConjugate formationPlatelets
1985
IgG‐mediated haemolysis masquerading as cold agglutinin‐induced anaemia complicating severe infection with Mycoplasma pneumoniae
Louie E, Ault K, Smith B, Hardman E, Quesenberry P. IgG‐mediated haemolysis masquerading as cold agglutinin‐induced anaemia complicating severe infection with Mycoplasma pneumoniae. European Journal Of Haematology 1985, 35: 264-269. PMID: 3933104, DOI: 10.1111/j.1600-0609.1985.tb01705.x.Peer-Reviewed Original ResearchConceptsCold agglutininsIgM cold agglutininsMycoplasma pneumoniaeMycoplasma infectionMycoplasma pneumoniaSevere infectionsSevere haemolysisHaemolytic anaemiaClinical relevancePatient's erythrocytesCryoglobulin fractionInfectionCareful evaluationHaemolysisPneumoniaPatientsAnemiaMechanism of haemolysisPneumoniaeAgglutininErythrocytesEtiologySephadex GTitres