Platelet PlA2 polymorphism enhances risk of neurocognitive decline after cardiopulmonary bypass
Mathew J, Rinder C, Howe J, Fontes M, Crouch J, Newman M, Phillips-Bute B, Smith B, Group T. Platelet PlA2 polymorphism enhances risk of neurocognitive decline after cardiopulmonary bypass. The Annals Of Thoracic Surgery 2001, 71: 663-666. PMID: 11235724, DOI: 10.1016/s0003-4975(00)02335-3.Peer-Reviewed Original ResearchConceptsMini-Mental State ExaminationPlA1/A1PlA1/A2Cardiopulmonary bypassNeurocognitive declinePlA2 polymorphismPlatelet GPIIIaState ExaminationBaseline Mini-Mental State ExaminationGreater neurocognitive declineProthrombotic genetic factorsPostoperative day 4Prothrombotic risk factorsEmbolic insultFrequent complicationPlA2 allelePlaque embolizationLocal thrombosisRisk factorsThrombotic processCardiovascular settingsPlA2 genotypeNeurocognitive changesDay 4Multivariate analysis