Reversibility of severe metabolic stress in stored platelets after in vitro plasma rescue or in vivo transfusion: restoration of secretory function and maintenance of platelet survival
Rinder HM, Snyder EL, Tracey JB, Dincecco D, Wang C, Baril L, Rinder CS, Smith BR. Reversibility of severe metabolic stress in stored platelets after in vitro plasma rescue or in vivo transfusion: restoration of secretory function and maintenance of platelet survival. Transfusion 2003, 43: 1230-1237. PMID: 12919425, DOI: 10.1046/j.1537-2995.2003.00484.x.Peer-Reviewed Original ResearchConceptsGlycoprotein IIb/IIIaAlpha-granule releaseAdverse metabolic conditionsIIb/IIIaPlatelet recoveryPlatelet concentratesMetabolic conditionsVivo platelet recoveryPlatelet secretory responseSevere metabolic stressOsmotic recoveryAgonist-induced bindingAutologous transfusionTransient derangementSecretory responseFunctional derangementFunctional abnormalitiesMembrane phosphatidylserine exposureMetabolic rescueNormal volunteersPlatelet survivalPosttransfusion recoveryPlatelet aggregationImproved functionSecretory function