The extracellular domain of CD45 controls association with the CD4-T cell receptor complex and the response to antigen-specific stimulation.
Leitenberg D, Novak TJ, Farber D, Smith BR, Bottomly K. The extracellular domain of CD45 controls association with the CD4-T cell receptor complex and the response to antigen-specific stimulation. Journal Of Experimental Medicine 1996, 183: 249-259. PMID: 8551228, PMCID: PMC2192406, DOI: 10.1084/jem.183.1.249.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAntigen PresentationBase SequenceCD4 AntigensCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell LineFlow CytometryImmunologic CappingLeukocyte Common AntigensLymphocyte ActivationMolecular Sequence DataPhenotypePhosphatidylinositol Diacylglycerol-LyasePhosphoric Diester HydrolasesProtein BindingReceptors, Antigen, T-CellRecombinant ProteinsStructure-Activity RelationshipTransfectionConceptsT cell receptorMolecular weight isoformsCD45 isoformsHigh molecular weight isoformsWeight isoformsAntigen-presenting cellsAntigen-specific stimulationT lymphocyte activationPanel of transfectantsLow molecular weight isoformsHigh molecular weight CD45 isoformsT helper 2 clonesCell receptor complexSpecific antigenT cell transfectants