1998
Differences in Platelet α-granule Release between Normals and Immune Thrombocytopenic Patients and between Young and Old Platelets
Rinder HM, Tracey JB, Recht M, DeCastro L, Rinder CS, McHugh C, Smith BR. Differences in Platelet α-granule Release between Normals and Immune Thrombocytopenic Patients and between Young and Old Platelets. Thrombosis And Haemostasis 1998, 80: 457-462. PMID: 9759627, DOI: 10.1055/s-0037-1615229.Peer-Reviewed Original ResearchConceptsImmune thrombocytopenic purpuraThrombin receptor agonist peptideAlpha-granule releaseITP patientsOld plateletsThrombocytopenic patientsImmune thrombocytopenic patientsPlatelet α-granule releaseΑ-granule releaseNormal human controlsMaintenance of hemostasisControl RPSerious bleedingThrombocytopenic purpuraMegakaryocytic hypoplasiaPatient groupReticulated plateletsNormal controlsPatientsPlatelet responseAgonist peptideYoung plateletsPlateletsHemostatic activityCD62P
1995
Nitroprusside Inhibition of Platelet Function Is Transient and Reversible by Catecholamine Priming
Harris S, Rinder C, Rinder H, Tracey J, Smith B, Hines R. Nitroprusside Inhibition of Platelet Function Is Transient and Reversible by Catecholamine Priming. Anesthesiology 1995, 83: 1145-1152.. PMID: 8533905, DOI: 10.1097/00000542-199512000-00003.Peer-Reviewed Original ResearchConceptsAlpha-granule releaseSodium nitroprusside infusionSodium nitroprussidePlatelet functionNitroprusside infusionPlatelet aggregationSodium nitroprusside administrationP-selectin expressionPlatelet-rich plasmaMeasures of plateletIntravenous crystalloidImpaired coagulationNitroprusside administrationAntiplatelet effectEpinephrine pretreatmentNormal volunteersVivo findingsHuman volunteersNitroprussideVivo inhibitionVitro inhibitionInhibitory effectSignificant inhibitionRapid reversibilityTime course
1994
Platelet alpha-granule release in cocaine users.
Rinder HM, Ault KA, Jatlow PI, Kosten TR, Smith BR. Platelet alpha-granule release in cocaine users. Circulation 1994, 90: 1162-1167. PMID: 7522132, DOI: 10.1161/01.cir.90.3.1162.Peer-Reviewed Original ResearchConceptsAlpha-granule releasePlatelet alpha-granule releaseCocaine useCocaine usersBaseline levelsHigher mean baseline levelsLong-term cocaine usePeak plasma cocaine levelsPlatelet P-selectin expressionMean baseline levelPlasma cocaine levelsP-selectin expressionPlatelet-rich thrombiPlacebo infusionFlow cytometric methodArterial occlusionBlinded infusionHigh basal levelsAcute increaseAtherosclerotic lesionsPlatelet activationCocaine levelsMean percentPlatelet agonistsBasal levels