2007
Leukocyte Effects of C5a-Receptor Blockade During Simulated Extracorporeal Circulation
Rinder CS, Smith MJ, Rinder HM, Cortright DN, Brodbeck RM, Krause JE, Smith BR. Leukocyte Effects of C5a-Receptor Blockade During Simulated Extracorporeal Circulation. The Annals Of Thoracic Surgery 2007, 83: 146-152. PMID: 17184649, DOI: 10.1016/j.athoracsur.2006.08.019.Peer-Reviewed Original ResearchConceptsC5a receptor blockadeC5a receptor antagonistReceptor antagonistExtracorporeal circulationReceptor blockadeCD11b upregulationElastase releasePlatelet P-selectin expressionComplement C5a anaphylatoxinNeutrophil CD11b upregulationSimulated Extracorporeal CirculationFresh heparinized whole bloodNeutrophil elastase releasePlasma interleukin-8P-selectin expressionInterleukin-8 releaseConjugate formationHeparinized whole bloodCardiopulmonary bypassInflammatory responseLeukocyte adhesive receptorsExtracorporeal circuitInterleukin-8Neutrophil chemotaxisDownregulatory effect
1994
Platelet alpha-granule release in cocaine users.
Rinder HM, Ault KA, Jatlow PI, Kosten TR, Smith BR. Platelet alpha-granule release in cocaine users. Circulation 1994, 90: 1162-1167. PMID: 7522132, DOI: 10.1161/01.cir.90.3.1162.Peer-Reviewed Original ResearchConceptsAlpha-granule releasePlatelet alpha-granule releaseCocaine useCocaine usersBaseline levelsHigher mean baseline levelsLong-term cocaine usePeak plasma cocaine levelsPlatelet P-selectin expressionMean baseline levelPlasma cocaine levelsP-selectin expressionPlatelet-rich thrombiPlacebo infusionFlow cytometric methodArterial occlusionBlinded infusionHigh basal levelsAcute increaseAtherosclerotic lesionsPlatelet activationCocaine levelsMean percentPlatelet agonistsBasal levelsNeutrophil but not Monocyte Activation Inhibits P-Selectin-Mediated Platelet Adhesion*
Rinder H, Tracey J, Rinder C, Leitenberg D, Smith B. Neutrophil but not Monocyte Activation Inhibits P-Selectin-Mediated Platelet Adhesion*. Thrombosis And Haemostasis 1994, 72: 750-756. PMID: 7534948, DOI: 10.1055/s-0038-1648953.Peer-Reviewed Original ResearchConceptsNeutrophil-platelet conjugatesP-selectinP-selectin-mediated platelet adhesionDREG-56Platelet activationL-selectinPlatelet P-selectin expressionP-selectin-expressing plateletsP-selectin-positive plateletsLeukocyte-platelet conjugatesNeutrophil-platelet adhesionPlatelet P-selectinP-selectin expressionWhole blood modelLeukocyte-platelet adhesionPlatelet adhesionNeutrophil activationLeukocyte activationNeutrophil adhesionBaseline levelsNeutrophilsUnstimulated leukocytesMonoclonal antibodiesEndothelial cellsImmediate rise