2007
Leukocyte Effects of C5a-Receptor Blockade During Simulated Extracorporeal Circulation
Rinder CS, Smith MJ, Rinder HM, Cortright DN, Brodbeck RM, Krause JE, Smith BR. Leukocyte Effects of C5a-Receptor Blockade During Simulated Extracorporeal Circulation. The Annals Of Thoracic Surgery 2007, 83: 146-152. PMID: 17184649, DOI: 10.1016/j.athoracsur.2006.08.019.Peer-Reviewed Original ResearchConceptsC5a receptor blockadeC5a receptor antagonistReceptor antagonistExtracorporeal circulationReceptor blockadeCD11b upregulationElastase releasePlatelet P-selectin expressionComplement C5a anaphylatoxinNeutrophil CD11b upregulationSimulated Extracorporeal CirculationFresh heparinized whole bloodNeutrophil elastase releasePlasma interleukin-8P-selectin expressionInterleukin-8 releaseConjugate formationHeparinized whole bloodCardiopulmonary bypassInflammatory responseLeukocyte adhesive receptorsExtracorporeal circuitInterleukin-8Neutrophil chemotaxisDownregulatory effect
1995
Nitroprusside Inhibition of Platelet Function Is Transient and Reversible by Catecholamine Priming
Harris S, Rinder C, Rinder H, Tracey J, Smith B, Hines R. Nitroprusside Inhibition of Platelet Function Is Transient and Reversible by Catecholamine Priming. Anesthesiology 1995, 83: 1145-1152.. PMID: 8533905, DOI: 10.1097/00000542-199512000-00003.Peer-Reviewed Original ResearchConceptsAlpha-granule releaseSodium nitroprusside infusionSodium nitroprussidePlatelet functionNitroprusside infusionPlatelet aggregationSodium nitroprusside administrationP-selectin expressionPlatelet-rich plasmaMeasures of plateletIntravenous crystalloidImpaired coagulationNitroprusside administrationAntiplatelet effectEpinephrine pretreatmentNormal volunteersVivo findingsHuman volunteersNitroprussideVivo inhibitionVitro inhibitionInhibitory effectSignificant inhibitionRapid reversibilityTime course
1994
Platelet alpha-granule release in cocaine users.
Rinder HM, Ault KA, Jatlow PI, Kosten TR, Smith BR. Platelet alpha-granule release in cocaine users. Circulation 1994, 90: 1162-1167. PMID: 7522132, DOI: 10.1161/01.cir.90.3.1162.Peer-Reviewed Original ResearchConceptsAlpha-granule releasePlatelet alpha-granule releaseCocaine useCocaine usersBaseline levelsHigher mean baseline levelsLong-term cocaine usePeak plasma cocaine levelsPlatelet P-selectin expressionMean baseline levelPlasma cocaine levelsP-selectin expressionPlatelet-rich thrombiPlacebo infusionFlow cytometric methodArterial occlusionBlinded infusionHigh basal levelsAcute increaseAtherosclerotic lesionsPlatelet activationCocaine levelsMean percentPlatelet agonistsBasal levelsNeutrophil but not Monocyte Activation Inhibits P-Selectin-Mediated Platelet Adhesion*
Rinder H, Tracey J, Rinder C, Leitenberg D, Smith B. Neutrophil but not Monocyte Activation Inhibits P-Selectin-Mediated Platelet Adhesion*. Thrombosis And Haemostasis 1994, 72: 750-756. PMID: 7534948, DOI: 10.1055/s-0038-1648953.Peer-Reviewed Original ResearchConceptsNeutrophil-platelet conjugatesP-selectinP-selectin-mediated platelet adhesionDREG-56Platelet activationL-selectinPlatelet P-selectin expressionP-selectin-expressing plateletsP-selectin-positive plateletsLeukocyte-platelet conjugatesNeutrophil-platelet adhesionPlatelet P-selectinP-selectin expressionWhole blood modelLeukocyte-platelet adhesionPlatelet adhesionNeutrophil activationLeukocyte activationNeutrophil adhesionBaseline levelsNeutrophilsUnstimulated leukocytesMonoclonal antibodiesEndothelial cellsImmediate rise
1993
Aspirin Does Not Inhibit Adenosine Diphosphate-Induced Platelet α-Granule Release
Rinder C, Student L, Bonan J, Rinder H, Smith B. Aspirin Does Not Inhibit Adenosine Diphosphate-Induced Platelet α-Granule Release. Blood 1993, 82: 505-512. PMID: 7687162, DOI: 10.1182/blood.v82.2.505.505.Peer-Reviewed Original ResearchConceptsP-selectin expressionAlpha-granule secretionPlatelet alpha-granule secretionAspirin treatmentP-selectinGranule secretionPlatelet alpha-granule releaseArachidonic acidCyclooxygenase-dependent metabolitesPlatelet surface expressionPlatelet α-granule releasePlatelet dense granule secretionAlpha-granule releaseΑ-granule releaseDense granule secretionPolymorphonuclear lymphocytesAmiloride treatmentLipoxygenase inhibitorsAspirinSecretionWhole bloodPlatelet-platelet interactionsTreatmentInvolvement of metabolitesPlateletsAspirin does not inhibit adenosine diphosphate-induced platelet alpha- granule release
Rinder C, Student L, Bonan J, Rinder H, Smith B. Aspirin does not inhibit adenosine diphosphate-induced platelet alpha- granule release. Blood 1993, 82: 505-512. DOI: 10.1182/blood.v82.2.505.bloodjournal822505.Peer-Reviewed Original ResearchP-selectin expressionAlpha-granule secretionPlatelet alpha-granule secretionAspirin treatmentP-selectinGranule secretionPlatelet alpha-granule releaseArachidonic acidCyclooxygenase-dependent metabolitesPlatelet surface expressionPlatelet dense granule secretionAlpha-granule releaseDense granule secretionPolymorphonuclear lymphocytesAmiloride treatmentLipoxygenase inhibitorsAspirinSecretionWhole bloodPlatelet-platelet interactionsTreatmentInvolvement of metabolitesPlateletsExpressionADP