2006
Antithrombin reduces monocyte and neutrophil CD11b up regulation in addition to blocking platelet activation during extracorporeal circulation
Rinder CS, Rinder HM, Smith MJ, Fitch JC, Tracey JB, Chandler WL, Rollins SA, Smith BR. Antithrombin reduces monocyte and neutrophil CD11b up regulation in addition to blocking platelet activation during extracorporeal circulation. Transfusion 2006, 46: 1130-1137. PMID: 16836559, DOI: 10.1111/j.1537-2995.2006.00861.x.Peer-Reviewed Original ResearchConceptsNeutrophil elastase releaseAnti-inflammatory activityAntithrombin IIICardiopulmonary bypassElastase releasePlatelet activationWhite blood cell activationDirect anti-inflammatory activitySystemic inflammatory reactionAbsence of endotheliumEndothelial effectsCardiac surgeryBlood cell activationAnticoagulant effectExtracorporeal circulationInflammatory reactionThrombin generationHigh doseClinical relevanceCell activationFibrin generationComplement activationThrombin activityStudy designCD11b
1995
CD4 and CD45 regulate qualitatively distinct patterns of calcium mobilization in individual CD4+ T cells
Leitenberg D, Constant S, Lu D, Smith B, Bottomly K. CD4 and CD45 regulate qualitatively distinct patterns of calcium mobilization in individual CD4+ T cells. European Journal Of Immunology 1995, 25: 2445-2451. PMID: 7589109, DOI: 10.1002/eji.1830250906.Peer-Reviewed Original ResearchConceptsIntracellular calcium concentrationCalcium mobilizationSustained increaseT cellsCell activationCalcium concentrationCross-linking CD4Antigen-presenting cellsIntracellular calcium mobilizationT cell interactionsT cell activationT cell receptor complexT cell receptor signalingDistinct patternsCell receptor signalingIndividual CD4Cell receptor complexCD4Extracellular calciumCD3Specific antigenCross-linking antibodiesCalcium spikesCalcium fluxReceptor signaling
1988
Phenotypic and functional characterization of human cytolytic T cells lacking expression of CD5.
Bierer BE, Nishimura Y, Burakoff SJ, Smith BR. Phenotypic and functional characterization of human cytolytic T cells lacking expression of CD5. Journal Of Clinical Investigation 1988, 81: 1390-1397. PMID: 2452832, PMCID: PMC442569, DOI: 10.1172/jci113468.Peer-Reviewed Original ResearchConceptsAnti-CD3 mAbNormal cytolytic activityCytolytic activityHuman cytolytic T cellsNormal individualsLymphocyte function-associated antigen-3Blood mononuclear cellsImmunofluorescence flow cytometryCytolytic T cellsExpression of CD5T lymphocyte clonesT cell activationSurface CD3Appropriate target cellsMononuclear cellsNormal CD5CD5 antigenT cellsIntracellular calciumLymphocyte clonesCD5Cell activationCell membrane glycoproteinAntigen 3Lymphoid phenotype