Effects of ε-Aminocaproic Acid and Aprotinin on Leukocyte–Platelet Adhesion in Patients Undergoing Cardiac Surgery
Greilich PE, Brouse CF, Rinder CS, Smith BR, Sandoval BA, Rinder HM, Eberhart RC, Jessen ME. Effects of ε-Aminocaproic Acid and Aprotinin on Leukocyte–Platelet Adhesion in Patients Undergoing Cardiac Surgery. Anesthesiology 2004, 100: 225-233. PMID: 14739793, DOI: 10.1097/00000542-200402000-00008.Peer-Reviewed Original ResearchConceptsEpsilon-aminocaproic acidCardiopulmonary bypassLeukocyte-platelet adhesionPlatelet activationPlatelet CD62PCardiac surgeryPlasmin activityAdministration of aprotininDouble-blind fashionMonocyte-platelet conjugatesActivation of leukocytesD-dimer formationConjugate formationAbility of aprotininMonocyte CD11bSaline groupCD11b expressionLeukocyte activationΕ-aminocaproic acidPatientsUseful markerClinical settingAprotininLeukocytesSurgery