2023
Pragmatic evaluation of events and benefits of lipid lowering in older adults (PREVENTABLE): Trial design and rationale
Joseph J, Pajewski N, Dolor R, Sellers M, Perdue L, Peeples S, Henrie A, Woolard N, Jones W, Benziger C, Orkaby A, Mixon A, VanWormer J, Shapiro M, Kistler C, Polonsky T, Chatterjee R, Chamberlain A, Forman D, Knowlton K, Gill T, Newby L, Hammill B, Cicek M, Williams N, Decker J, Ou J, Rubinstein J, Choudhary G, Gazmuri R, Schmader K, Roumie C, Vaughan C, Effron M, Cooper‐DeHoff R, Supiano M, Shah R, Whittle J, Hernandez A, Ambrosius W, Williamson J, Alexander K, Group P. Pragmatic evaluation of events and benefits of lipid lowering in older adults (PREVENTABLE): Trial design and rationale. Journal Of The American Geriatrics Society 2023, 71: 1701-1713. PMID: 37082807, PMCID: PMC10258159, DOI: 10.1111/jgs.18312.Peer-Reviewed Original ResearchConceptsOlder adultsHigh-intensity statin therapyRandomized pragmatic clinical trialCognitive testingBenefits of lipidInitiation of statinsBenefits of statinsNational Death Index searchEffect of statinsPragmatic clinical trialsCommunity-dwelling adultsMild cognitive impairmentLow participant burdenBaseline cognitive testingElectronic health recordsCardiovascular deathCardiovascular eventsCoronary revascularizationLipid panelStatin therapyStatin useUnstable anginaHeart failurePrimary outcomeMyocardial infarction
2018
Contemporary approach to stroke prevention in atrial fibrillation: Risks, benefits, and new options
Stock J, Malm BJ. Contemporary approach to stroke prevention in atrial fibrillation: Risks, benefits, and new options. Trends In Cardiovascular Medicine 2018, 28: 469-480. PMID: 29739702, DOI: 10.1016/j.tcm.2018.03.004.Peer-Reviewed Original ResearchConceptsAtrial fibrillationStroke riskRisk factorsStroke risk factorsDirect oral anticoagulantsStrong risk factorStandard of careOral anticoagulantsMost patientsSelect patientsThromboembolic complicationsCoronary diseaseHeart failureAppropriate therapyCommon diagnosisRisk stratificationFibrillationPatientsMechanical interventionRiskTherapyNew optionsAccurate assessmentAnticoagulationHypertension