2024
The Melanocortin and Endorphin Neuropeptides in Patients with Restless Legs Syndrome
Koo B, Abdelfattah A, Eysa A, Lu L. The Melanocortin and Endorphin Neuropeptides in Patients with Restless Legs Syndrome. Annals Of Neurology 2024, 95: 688-699. PMID: 38308537, DOI: 10.1002/ana.26876.Peer-Reviewed Original ResearchRestless legs syndromeRestless legs syndrome patientsRestless legs syndrome severityAdrenocorticotropin hormoneCerebrospinal fluidB-endorphinPro-opiomelanocortinA-MSHPlasma adrenocorticotropin hormoneRLS participantsInternational RLS Study Group Severity ScaleRLS patientsAssessed plasmaPain symptomsLumbar punctureA-melanocyte-stimulating hormoneMatched controlsPatientsHormoneSeverity ScaleSensory discomfortPlasmaSeverityMelanocortin hormonesHyperalgesia
2016
Restless Legs Syndrome: Current Concepts about Disease Pathophysiology
Koo BB, Bagai K, Walters AS. Restless Legs Syndrome: Current Concepts about Disease Pathophysiology. Tremor And Other Hyperkinetic Movements 2016, 6: 401. PMID: 27536462, PMCID: PMC4961894, DOI: 10.7916/d83j3d2g.Peer-Reviewed Original ResearchRestless legs syndromeBrain areasLegs syndromeSerotonergic systemCingulate cortexIron deficiencyStructural brain abnormalitiesPost-central gyrusWidespread brain areasSensory brain areasEnglish language papersRLS patientsSensorimotor disorderBrain abnormalitiesAnatomic locationDisease pathophysiologySecondary responseBrain regionsPathophysiologyConsistent findingLanguage papersCurrent conceptsOpioidsGlutamatergicDopaminergic