Restless Legs Syndrome and Depression: Effect Mediation by Disturbed Sleep and Periodic Limb Movements
Koo BB, Blackwell T, Lee HB, Stone KL, Louis ED, Redline S, Group O. Restless Legs Syndrome and Depression: Effect Mediation by Disturbed Sleep and Periodic Limb Movements. American Journal Of Geriatric Psychiatry 2016, 24: 1105-1116. PMID: 27526989, PMCID: PMC5241001, DOI: 10.1016/j.jagp.2016.04.003.Peer-Reviewed Original ResearchConceptsSevere restless legs syndromeRestless legs syndromePeriodic limb movementsDepressive symptomsLegs syndromeSleep disturbancesMild restless legs syndromeFurther adjustmentAssociation of RLSLimb movementsCardiovascular risk factorsApnea-hypopnea indexBody mass indexPotential mediatorsCross-sectional analysisEffect sizeDopaminergic medicationMass indexOsteoporotic fracturesPLMS indexDisturbed sleepRisk factorsGDS scoresPhysical activitySleep efficiency