The Acidic Domain of Hepatitis C Virus NS4A Contributes to RNA Replication and Virus Particle Assembly
Phan T, Kohlway A, Dimberu P, Pyle AM, Lindenbach BD. The Acidic Domain of Hepatitis C Virus NS4A Contributes to RNA Replication and Virus Particle Assembly. Journal Of Virology 2010, 85: 1193-1204. PMID: 21047963, PMCID: PMC3020511, DOI: 10.1128/jvi.01889-10.Peer-Reviewed Original ResearchConceptsVirus particle assemblyAcidic domainGenome replicationAssembly defectsEnzyme complexSevere defectsMembrane-bound enzyme complexRNA replicationTerminal acidic domainNS3-4AAlanine-scanning mutagenesisSecond-site mutationsViral genome replicationHepatitis C virus (HCV) NS3-4AGenetic interactionsRNA helicaseParticle assemblyReplication defectScanning mutagenesisMutant formsVirus assemblySerine proteasesEnzymatic activityATPase activityMutants