2013
The ins and outs of hepatitis C virus entry and assembly
Lindenbach BD, Rice CM. The ins and outs of hepatitis C virus entry and assembly. Nature Reviews Microbiology 2013, 11: 688-700. PMID: 24018384, PMCID: PMC3897199, DOI: 10.1038/nrmicro3098.Peer-Reviewed Original ResearchConceptsHCV particlesRNA virusesPositive-strand RNA virusesSignal transduction eventsSerum lipoproteinsCell surface proteinsHepatitis C Virus EntryNumerous cell surface proteinsNon-structural proteinsNew structural informationC virus entrySecretory pathwayTransduction eventsUncharacterized mechanismMembrane fusionHCV particle assemblyCellular processingSurface proteinsC virus
2010
Hepatitis C Virus NS2 Coordinates Virus Particle Assembly through Physical Interactions with the E1-E2 Glycoprotein and NS3-NS4A Enzyme Complexes
Stapleford KA, Lindenbach BD. Hepatitis C Virus NS2 Coordinates Virus Particle Assembly through Physical Interactions with the E1-E2 Glycoprotein and NS3-NS4A Enzyme Complexes. Journal Of Virology 2010, 85: 1706-1717. PMID: 21147927, PMCID: PMC3028914, DOI: 10.1128/jvi.02268-10.Peer-Reviewed Original ResearchConceptsProtein complexesBlue native polyacrylamide gel electrophoresisEnzyme complexHepatitis C virus NS2Early secretory pathwayProtein complex formationHepatitis C Virus NS2 ProteinViral proteinsNative polyacrylamide gel electrophoresisParticle assemblyHCV particle assemblyVirus particle assemblyGenetic interactionsSecretory pathwayComplex interactsCentral organizing roleInteraction partnersE1-E2 glycoproteinsNS2 proteinVirus assemblyNonstructural proteinsPolyacrylamide gel electrophoresisP7 proteinProteinOrganizing role