2006
Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro
Lindenbach BD, Meuleman P, Ploss A, Vanwolleghem T, Syder AJ, McKeating JA, Lanford RE, Feinstone SM, Major ME, Leroux-Roels G, Rice CM. Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 3805-3809. PMID: 16484368, PMCID: PMC1533780, DOI: 10.1073/pnas.0511218103.Peer-Reviewed Original ResearchConceptsHepatitis C virusC virusCell culture-grown hepatitis C virusChronic liver diseaseHuman liver graftsHCV culture systemsHCV life cycleLong-term infectionLiver graftsLiver diseaseCurrent therapiesHepatocellular carcinomaCell culturesInfectious virusImproved infectivityMajor causeViral infectivityVivo cultureHCVccVirusInfectious cloneVivo dissectionInfectivityCulture systemCirrhosisInvestigations into the receptor requirements of Hepatitis C Virus (HCV) pseudoparticles and cell culture grown virions
von Hahn T, Flint M, Lindenbach B, Boullier A, Quehenberger O, Rice C, McKeating J. Investigations into the receptor requirements of Hepatitis C Virus (HCV) pseudoparticles and cell culture grown virions. Zeitschrift Für Gastroenterologie 2006, 44 DOI: 10.1055/s-2006-931763.Peer-Reviewed Original Research
2005
Unravelling hepatitis C virus replication from genome to function
Lindenbach BD, Rice CM. Unravelling hepatitis C virus replication from genome to function. Nature 2005, 436: 933-938. PMID: 16107832, DOI: 10.1038/nature04077.Peer-Reviewed Original ResearchComplete Replication of Hepatitis C Virus in Cell Culture
Lindenbach BD, Evans MJ, Syder AJ, Wölk B, Tellinghuisen TL, Liu CC, Maruyama T, Hynes RO, Burton DR, McKeating JA, Rice CM. Complete Replication of Hepatitis C Virus in Cell Culture. Science 2005, 309: 623-626. PMID: 15947137, DOI: 10.1126/science.1114016.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalAntibodies, ViralAntigens, CDAntiviral AgentsCell Line, TumorCentrifugation, Density GradientCulture Media, ConditionedGenome, ViralHepacivirusHumansInterferon-alphaMutationNeutralization TestsRepliconRNA, ViralSerial PassageTetraspanin 28TransfectionViral Envelope ProteinsViral Nonstructural ProteinsVirionVirus CultivationVirus ReplicationConceptsHepatitis C virus (HCV) life cyclePutative HCV receptorFull-length HCV genomeHepatitis C virusViral glycoprotein E2Cell culturesVirus particlesHCV receptorsC virusVirus life cycleHCV genomeGlycoprotein E2Important human pathogenAntiviral compoundsImproved antiviralsViral entryMonoclonal antibodiesCellular expressionInfectious unitsHuman pathogensVitro systemHCVccAntiviralsReplication