Chronic Polypharmacy with Increasing Drug Burden Index Exacerbates Frailty and Impairs Physical Function, with Effects Attenuated by Deprescribing, in Aged Mice
Mach J, Gemikonakli G, Logan C, Vander Wyk B, Allore H, Ekambareshwar S, Kane AE, Howlett SE, de Cabo R, Le Couteur DG, Hilmer SN. Chronic Polypharmacy with Increasing Drug Burden Index Exacerbates Frailty and Impairs Physical Function, with Effects Attenuated by Deprescribing, in Aged Mice. The Journals Of Gerontology Series A 2020, 76: 1010-1018. PMID: 32147704, PMCID: PMC8140051, DOI: 10.1093/gerona/glaa060.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDeprescriptionsDrug-Related Side Effects and Adverse ReactionsFrailtyMaleMiceMice, Inbred C57BLPolypharmacyConceptsDrug Burden IndexPhysical functionChronic polypharmacyOlder ageObservational studyDrug Burden Index (DBI) scoreHarms outweigh benefitsMale C57BL/6J miceClinical observational studyDose of drugFirst preclinical studyImpairs physical functionNumber of drugsGeriatric outcomesSupervised withdrawalDrug withdrawalAged miceBurden indexC57BL/6J micePreclinical modelsPolypharmacyPreclinical studiesDBI scoreTreatment groupsHealth outcomes