2016
The Methylation-Sensitive Enhancer Derare Maintains Hematopoietic Stem Cells through Regulation of Hoxb Cluster
Qian P, De Kumar B, Ahn Y, Nolte C, Paulson A, He X, Li Z, Perry J, Zhao M, Tao F, Krumlauf R, Li L. The Methylation-Sensitive Enhancer Derare Maintains Hematopoietic Stem Cells through Regulation of Hoxb Cluster. Blood 2016, 128: 725. DOI: 10.1182/blood.v128.22.725.725.Peer-Reviewed Original ResearchHematopoietic stem cellsHoxB gene expressionGene expressionLT-HSCsHOXB clusterHOXB cluster genesCluster genesHoxb genesCluster gene expressionChIP-seq analysisCis-regulatory elementsTrans-acting factorsFunctional hematopoietic stem cellsNext-generation sequencing technologiesStem cellsDNA methylation analysisCancer Genome Atlas (TCGA) projectHematopoietic cell typesLong-term reconstitution capacityHSC maintenancePutative enhancersTranscriptome analysisRegulatory networksRNA-seqGenetic regulatory networks
2015
A Conserved Cis-Regulatory Retinoic Acid Responsive Element Is Essential for Maintenance of Primitive Hematopoietic Stem Cells through Regulation of Hoxb Cluster
Qian P, Ahn Y, De Kumar B, Nolte C, He X, Paulson A, Perry J, Li Z, Krumlauf R, Li L. A Conserved Cis-Regulatory Retinoic Acid Responsive Element Is Essential for Maintenance of Primitive Hematopoietic Stem Cells through Regulation of Hoxb Cluster. Blood 2015, 126: 2377. DOI: 10.1182/blood.v126.23.2377.2377.Peer-Reviewed Original ResearchRetinoic acid responsive elementHOXB clusterHematopoietic stem cellsAcid-responsive elementPrimitive hematopoietic stem cellsLT-HSCsHox clustersHox genesHigh-throughput transcriptome analysisResponsive elementIndividual Hox genesCell typesMultiple Hox genesStem cell maintenanceFunctional hematopoietic stem cellsHoxB gene expressionStem cellsMultiple blood cell typesNervous system developmentCentral nervous system developmentLong-term reconstitution capacityHOXB cluster genesKnockout mouse modelBlood cell typesVertebrate species