2020
Analysis of DNA Methylation Changes in Mice Mediated by Early‐life Exposure to the Antidepressant S‐citalopram
Rodriquez M, Shetty M, Black E, Kretschmar M, Perley D, De Kumar B, Henry L. Analysis of DNA Methylation Changes in Mice Mediated by Early‐life Exposure to the Antidepressant S‐citalopram. The FASEB Journal 2020, 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.06398.Peer-Reviewed Original ResearchMethylation changesSelective serotonin reuptake inhibitorsGenome-wide scaleDNA methylation changesSingle amino acid substitutionDNA methylation analysisSpecific methylation changesAmino acid substitutionsExpression changesMolecular mechanismsAcid substitutionsMethylation analysisSerotonin transporter blockadeSerotonin reuptake inhibitorsEarly life exposurePost-analysis methodsEarly developmentMice MediatedTransgenic miceReuptake inhibitorsTransporter blockadeMale miceS-citalopramSerotonin transporterSignificant risk
2016
The Methylation-Sensitive Enhancer Derare Maintains Hematopoietic Stem Cells through Regulation of Hoxb Cluster
Qian P, De Kumar B, Ahn Y, Nolte C, Paulson A, He X, Li Z, Perry J, Zhao M, Tao F, Krumlauf R, Li L. The Methylation-Sensitive Enhancer Derare Maintains Hematopoietic Stem Cells through Regulation of Hoxb Cluster. Blood 2016, 128: 725. DOI: 10.1182/blood.v128.22.725.725.Peer-Reviewed Original ResearchHematopoietic stem cellsHoxB gene expressionGene expressionLT-HSCsHOXB clusterHOXB cluster genesCluster genesHoxb genesCluster gene expressionChIP-seq analysisCis-regulatory elementsTrans-acting factorsFunctional hematopoietic stem cellsNext-generation sequencing technologiesStem cellsDNA methylation analysisCancer Genome Atlas (TCGA) projectHematopoietic cell typesLong-term reconstitution capacityHSC maintenancePutative enhancersTranscriptome analysisRegulatory networksRNA-seqGenetic regulatory networks