A Conserved Cis-Regulatory Retinoic Acid Responsive Element Is Essential for Maintenance of Primitive Hematopoietic Stem Cells through Regulation of Hoxb Cluster
Qian P, Ahn Y, De Kumar B, Nolte C, He X, Paulson A, Perry J, Li Z, Krumlauf R, Li L. A Conserved Cis-Regulatory Retinoic Acid Responsive Element Is Essential for Maintenance of Primitive Hematopoietic Stem Cells through Regulation of Hoxb Cluster. Blood 2015, 126: 2377. DOI: 10.1182/blood.v126.23.2377.2377.Peer-Reviewed Original ResearchRetinoic acid responsive elementHOXB clusterHematopoietic stem cellsAcid-responsive elementPrimitive hematopoietic stem cellsLT-HSCsHox clustersHox genesHigh-throughput transcriptome analysisResponsive elementIndividual Hox genesCell typesMultiple Hox genesStem cell maintenanceFunctional hematopoietic stem cellsHoxB gene expressionStem cellsMultiple blood cell typesNervous system developmentCentral nervous system developmentLong-term reconstitution capacityHOXB cluster genesKnockout mouse modelBlood cell typesVertebrate species