2014
Hand transplants and the mandate for tolerance
Koulmanda M, Pomahac B, Fan Z, Murphy G, Strom T. Hand transplants and the mandate for tolerance. Current Opinion In Organ Transplantation 2014, Publish Ahead of Print: &na;. PMID: 25373855, PMCID: PMC4352932, DOI: 10.1097/mot.0000000000000138.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGraft RejectionHand TransplantationHumansImmune ToleranceImmunologic MemoryInflammationInterleukin-2ConceptsHand transplantationIL-2Hand transplantLow-dose IL-2IL-2-based therapyBalance of immunityDrug-free toleranceRegulatory T cellsUse of immunosuppressionRecent clinical trialsLife-long immunosuppressionInduction of toleranceNonhuman primate modelShort-term treatmentDrug minimizationPosttransplant periodInflammatory processClinical trialsPrimate modelT cellsPreclinical demonstrationComposite allograftsAdverse inflammationTransplantationTransplant
2007
Safety Evaluation of Topically Applied Amitriptyline in Porcine Full-Thickness Wounds
Pomahac B, Zuhaili B, Kudsi Y, Bleiziffer O, Velander P, Eriksson E, Gerner P. Safety Evaluation of Topically Applied Amitriptyline in Porcine Full-Thickness Wounds. Regional Anesthesia & Pain Medicine 2007, 32: 377-381. PMID: 17961834, DOI: 10.1016/j.rapm.2007.06.003.Peer-Reviewed Original ResearchConceptsFull-thickness woundsPorcine full-thickness woundsSerum levelsWound chambersTopical applicationWound contractionEffects of amitriptylineManagement of painDaily topical applicationHigher serum levelsExcised burn woundsFull-thickness skin biopsiesOvert toxic effectsLevels of amitriptylineTricyclic antidepressant amitriptylineNeuropathic painPain clinicHistopathological findingsNormal salineSkin biopsiesHistological assessmentAntidepressant amitriptylineDay 2Control groupAmitriptyline