2021
Immunoregulatory and lipid presentation pathways are upregulated in human face transplant rejection
Win T, Crisler W, Dyring-Andersen B, Lopdrup R, Teague J, Zhan Q, Barrera V, Sui S, Tasigiorgos S, Murakami N, Chandraker A, Tullius S, Pomahac B, Riella L, Clark R. Immunoregulatory and lipid presentation pathways are upregulated in human face transplant rejection. Journal Of Clinical Investigation 2021, 131 PMID: 33667197, PMCID: PMC8262560, DOI: 10.1172/jci135166.Peer-Reviewed Original ResearchConceptsVCA rejectionTransplant rejectionT cellsTissue injuryGene expression profilingAntigen-presenting cell activationT-cell receptor sequencingSolid organ transplantsCell receptor sequencingT cell activation pathwaysAntigen-specific activationProliferative T cellsCell activation pathwaysNovo Nordisk FoundationAmerican SocietyExpression profilingFace transplant patientsTransplant patientsImmunologic pathwaysImmunoregulatory networkSkin biopsiesImmunomodulatory pathwaysLimb transplantsLundbeck FoundationTransplant Research
2019
The Evolving Clinical Presentation of Acute Rejection in Facial Transplantation
Haug V, Kollar B, Obed D, Kiwanuka H, Turk M, Wo L, Tasigiorgos S, Kueckelhaus M, Riella L, Pomahac B. The Evolving Clinical Presentation of Acute Rejection in Facial Transplantation. Facial Plastic Surgery & Aesthetic Medicine 2019, 21: 278-285. PMID: 30998810, PMCID: PMC6646986, DOI: 10.1001/jamafacial.2019.0076.Peer-Reviewed Original ResearchConceptsAcute rejectionSubtherapeutic tacrolimus levelsClinical signsRejection episodesImmunosuppressive therapySubclinical rejectionTacrolimus levelsMedical recordsOdds ratioFacial transplantationDiagnostic valueSignificant associationSingle-center cohort studyLate rejection episodesProtocol skin biopsiesSecond posttransplant yearSymptoms of rejectionTacrolimus blood levelsSecond postoperative yearReliable clinical signFull facial transplantationPostoperative yearPosttransplant yearYears posttransplantationAllograft rejectionFive-Year Follow-up after Face Transplantation
Tasigiorgos S, Kollar B, Turk M, Perry B, Alhefzi M, Kiwanuka H, Nizzi M, Marty F, Chandraker A, Tullius S, Riella L, Pomahac B. Five-Year Follow-up after Face Transplantation. New England Journal Of Medicine 2019, 380: 2579-2581. PMID: 31141626, DOI: 10.1056/nejmc1810468.Peer-Reviewed Original Research
2018
Quality of Life and Psychosocial Functioning 2 Years Following Facial Transplantation
Oser M, Nizzi M, Zinser J, Turk M, Epstein R, Bueno E, Gitlin D, Pomahac B. Quality of Life and Psychosocial Functioning 2 Years Following Facial Transplantation. Journal Of The Academy Of Consultation-Liaison Psychiatry 2018, 59: 591-600. PMID: 29861176, DOI: 10.1016/j.psym.2018.04.005.Peer-Reviewed Original ResearchConceptsPhysical health QoLDepressive symptomsHealth statusPhysical health-related QoLFace transplantationOverall depressive symptomsHealth-related QoLMental health QOLSubthreshold depressive symptomsSevere facial disfigurementFacial transplantationQuality of lifeImmunosuppression inductionMonths posttransplantationDepressive episodePhysical QoLHigh health statusPatientsTransplantationQoLPsychosocial functioningLife outcomesCeiling effectsFacial disfigurementSymptoms
2016
A Retrospective Analysis of Secondary Revisions after Face Transplantation
Aycart M, Alhefzi M, Kueckelhaus M, Krezdorn N, Bueno E, Caterson E, Pribaz J, Pomahac B. A Retrospective Analysis of Secondary Revisions after Face Transplantation. Plastic & Reconstructive Surgery 2016, 138: 690e-701e. PMID: 27673540, DOI: 10.1097/prs.0000000000002605.Peer-Reviewed Original ResearchConceptsFree tissue transferSecondary revisionFace transplantationMedical recordsRetrospective analysisTissue transferCLINICAL QUESTION/LEVELA Retrospective AnalysisDevastating facial injuriesSkin flap lossMedian time intervalAutologous free tissue transferPatients' medical recordsLocal tissue rearrangementAcute rejectionMaintenance immunosuppressionPulse steroidsPostoperative complicationsMajor infectionSuperficial musculoaponeurotic system plicationCertain patientsOperative reportsRevision surgeryFlap lossRevision proceduresCodominant Role of Interferon‐γ– and Interleukin‐17–Producing T Cells During Rejection in Full Facial Transplant Recipients
Borges T, O'Malley J, Wo L, Murakami N, Smith B, Azzi J, Tripathi S, Lane J, Bueno E, Clark R, Tullius S, Chandraker A, Lian C, Murphy G, Strom T, Pomahac B, Najafian N, Riella L. Codominant Role of Interferon‐γ– and Interleukin‐17–Producing T Cells During Rejection in Full Facial Transplant Recipients. American Journal Of Transplantation 2016, 16: 2158-2171. PMID: 26749226, PMCID: PMC4979599, DOI: 10.1111/ajt.13705.Peer-Reviewed Original ResearchConceptsDe novo donor-specific antibody developmentDe novo donor-specific antibodiesInterleukin-17-producing T cellsT helper 2 cell phenotypeFacial transplantationDonor-specific antibody developmentNovo donor-specific antibodiesChemotactic protein-1 levelsPeripheral blood mononuclear cellsAcute cellular rejectionAnti-HLA antibodiesDonor-specific antibodiesFollicular helper cellsImmune cell subsetsProtein-1 levelsBlood mononuclear cellsMedium-term outcomesSkin biopsy specimensFull facial transplantationCellular rejection processLife-changing procedureCellular rejectionCodominant roleDonor alloreactivityTransplant recipientsFunctional Outcomes after Bilateral Hand Transplantation
Singh M, Sisk G, Carty M, Sampson C, Blazar P, Dyer G, Earp B, Pribaz J, Pomahac B, Talbot S. Functional Outcomes after Bilateral Hand Transplantation. Plastic & Reconstructive Surgery 2016, 137: 185-189. PMID: 26710022, DOI: 10.1097/prs.0000000000001872.Peer-Reviewed Original ResearchConceptsBilateral hand transplantationHand transplantationFunctional outcomeHand scoreOutcome measuresShort Form-36 Health SurveyCLINICAL QUESTION/LEVELBilateral hand transplantMid-forearm levelFirst successful hand transplantationFunctional outcome measuresHand transplantHealth SurveyFunctional gainsTherapy measuresSystem scoreTransplantationPatientsScore systemMultiple studiesOutcomesScoresObjective scoresDisabilityConsiderable variability
2015
Transformation of Face Transplants: Volumetric and Morphologic Graft Changes Resemble Aging After Facial Allotransplantation
Kueckelhaus M, Turk M, Kumamaru K, Wo L, Bueno E, Lian C, Alhefzi M, Aycart M, Fischer S, De Girolami U, Murphy G, Rybicki F, Pomahac B. Transformation of Face Transplants: Volumetric and Morphologic Graft Changes Resemble Aging After Facial Allotransplantation. American Journal Of Transplantation 2015, 16: 968-978. PMID: 26639618, DOI: 10.1111/ajt.13544.Peer-Reviewed Original ResearchConceptsLong-term outcomesFacial allograftFacial allotransplantationSuperior long-term outcomesShort-term resultsRisk-benefit assessmentSoft tissue volumeSignificant volume lossTransplant recipientsVolume lossDiagnostic evaluationDonor selectionMuscle biopsyHistological evaluationComputed tomographyBone atrophyAllograftsFuture clinical routineNormal anatomyRecipient tissuesAllotransplantationClinical routineMorphometric changesSoft tissueMuscle fibersNoninvasive Monitoring of Immune Rejection in Face Transplant Recipients
Kueckelhaus M, Imanzadeh A, Fischer S, Kumamaru K, Alhefzi M, Bueno E, Wake N, Gerhard-Herman M, Rybicki F, Pomahac B. Noninvasive Monitoring of Immune Rejection in Face Transplant Recipients. Plastic & Reconstructive Surgery 2015, 136: 1082-1089. PMID: 26505709, DOI: 10.1097/prs.0000000000001703.Peer-Reviewed Original ResearchConceptsFace transplant recipientsTransplant recipientsChronic rejectionCLINICAL QUESTION/LEVELAllograft biopsy specimensTotal vessel diameterSolid organ allograftsAllograft lossOrgan allograftsPostsurgical monitoringFlap arteryControl subjectsBiopsy specimensIntimal thicknessClinical signsRadial arteryThicker intimaUltrasound biomicroscopyFacial arteryMedia thicknessHistologic analysisImmune rejectionArteryRecipientsInterobserver correlation
2014
Functional Outcomes of Face Transplantation
Fischer S, Kueckelhaus M, Pauzenberger R, Bueno E, Pomahac B. Functional Outcomes of Face Transplantation. American Journal Of Transplantation 2014, 15: 220-233. PMID: 25359281, DOI: 10.1111/ajt.12956.Peer-Reviewed Original Research
2013
Lessons Learned from Simultaneous Face and Bilateral Hand Allotransplantation
Carty M, Hivelin M, Dumontier C, Talbot S, Benjoar M, Pribaz J, Lantieri L, Pomahac B. Lessons Learned from Simultaneous Face and Bilateral Hand Allotransplantation. Plastic & Reconstructive Surgery 2013, 132: 423-432. PMID: 23584623, DOI: 10.1097/prs.0b013e318295883d.Peer-Reviewed Original ResearchFacial allotransplantation: A 3-year follow-up report
Diaz-Siso J, Parker M, Bueno E, Sisk G, Pribaz J, Eriksson E, Annino D, Tullius S, Pomahac B. Facial allotransplantation: A 3-year follow-up report. Journal Of Plastic Reconstructive & Aesthetic Surgery 2013, 66: 1458-1463. PMID: 23911716, DOI: 10.1016/j.bjps.2013.06.046.Peer-Reviewed Original ResearchConceptsQuality of lifeFunctional recoveryFace transplantationFirst postoperative yearPatients' functional recoveryPost-operative monthHigh-voltage burnsSatisfactory aesthetic resultsFace transplant patientsSevere facial defectsImmunosuppression dosesSteroid therapyPostoperative yearTransplant patientsMale patientsNormal sensationImmunologic complicationsWomen's HospitalMotor functionSurgical techniquePatient reportsReconstructive surgeryClose monitoringMultidisciplinary teamOccupational therapy
2012
Psychosocial Changes 6 Months after Face Transplantation
Chang G, Pomahac B. Psychosocial Changes 6 Months after Face Transplantation. Journal Of The Academy Of Consultation-Liaison Psychiatry 2012, 54: 367-371. PMID: 23194929, PMCID: PMC3593952, DOI: 10.1016/j.psym.2012.07.012.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdultFacial TransplantationFemaleFollow-Up StudiesHumansInterpersonal RelationsInterview, PsychologicalLinear ModelsMaleOutcome Assessment, Health CarePostoperative PeriodPsychiatric Status Rating ScalesQuality of LifeSelf ConceptSurveys and QuestionnairesTime FactorsConceptsMental healthComprehensive psychiatric assessmentChanges 6 monthsCommon clinical practiceFull facial transplantationNovel surgical procedureMOS SF-12Facial transplantationOverall mental healthTransplantation programPsychosocial statusSurgical proceduresEQ-5D.Life measuresPsychiatric assessmentClinical practiceTransplantationPsychosocial changesFace transplantationMonthsRecipientsSurgeryMeasures 3Assessment protocolSame periodAbdominal wall reconstruction using a non-cross-linked porcine dermal scaffold: a follow-up study
Diaz-Siso J, Bueno E, Pomahac B. Abdominal wall reconstruction using a non-cross-linked porcine dermal scaffold: a follow-up study. Hernia 2012, 17: 37-44. PMID: 22707311, DOI: 10.1007/s10029-012-0927-0.Peer-Reviewed Original ResearchConceptsAbdominal wall reconstructionWall reconstructionMulti-organ failureLong-term outcomesLarger patient populationComplicated abdominal wallAbdominal wall defectAbdominal wall repairMean followMost patientsAnalysis of demographicsPatient populationIntraperitoneal techniqueSurgical techniqueComplex abdominal wall defectsAbdominal wallProsthetic meshPatientsComplicationsWall repairSuccessful outcomeConclusionsThis studyWall defectDermal scaffoldsInitial report
2011
Three Patients with Full Facial Transplantation
Pomahac B, Pribaz J, Eriksson E, Bueno E, Diaz-Siso J, Rybicki F, Annino D, Orgill D, Caterson E, Caterson S, Carty M, Chun Y, Sampson C, Janis J, Alam D, Saavedra A, Molnar J, Edrich T, Marty F, Tullius S. Three Patients with Full Facial Transplantation. New England Journal Of Medicine 2011, 366: 715-722. PMID: 22204672, DOI: 10.1056/nejmoa1111432.Peer-Reviewed Original ResearchConceptsFull face transplantFull facial transplantationFacial transplantationAcute rejectionPostoperative complicationsSensory nervesSevere deformityFunctional restorationPatientsSingle episodeFacial allograftTransplantationFacial appearanceConventional reconstructionComplicationsAllograftsNerveGlucocorticoidsTransplantDeformityCoaptationMonths
2009
Use of a non–cross-linked porcine dermal scaffold in abdominal wall reconstruction
Pomahac B, Aflaki P. Use of a non–cross-linked porcine dermal scaffold in abdominal wall reconstruction. The American Journal Of Surgery 2009, 199: 22-27. PMID: 19427629, DOI: 10.1016/j.amjsurg.2008.12.033.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal WallAdultAgedAged, 80 and overAnimalsBiocompatible MaterialsCohort StudiesCollagenFemaleFollow-Up StudiesHernia, AbdominalHernia, VentralHumansMaleMiddle AgedPlastic Surgery ProceduresRetrospective StudiesSeverity of Illness IndexSurgical Wound DehiscenceSuture TechniquesSwineTensile StrengthTreatment OutcomeWound HealingYoung AdultConceptsAbdominal wall reconstructionSuperficial wound dehiscenceAbdominal wallComplex abdominal wallWall reconstructionWound dehiscencePorcine dermalProsthetic meshRetrospective chart reviewIntra-abdominal catastropheSurgical site infectionLarge incisional herniasGiant ventral herniasComplicated abdominal wallMean followMultiorgan failureAbdominal traumaEmergency surgeryOpen abdomenChart reviewSite infectionAbdominal closureFistula formationWound infectionIncisional herniaEvaluation of appearance transfer and persistence in central face transplantation: A computer simulation analysis
Pomahac B, Aflaki P, Nelson C, Balas B. Evaluation of appearance transfer and persistence in central face transplantation: A computer simulation analysis. Journal Of Plastic Reconstructive & Aesthetic Surgery 2009, 63: 733-738. PMID: 19398394, DOI: 10.1016/j.bjps.2009.01.078.Peer-Reviewed Original Research
2007
The Role of Free-Tissue Transfer for Head and Neck Burn Reconstruction
Parrett B, Pomahac B, Orgill D, Pribaz J. The Role of Free-Tissue Transfer for Head and Neck Burn Reconstruction. Plastic & Reconstructive Surgery 2007, 120: 1871-1878. PMID: 18090749, DOI: 10.1097/01.prs.0000287272.28417.14.Peer-Reviewed Original ResearchConceptsFree flapBurn reconstructionTissue transferMean patient ageMedian hospital stayPercent of flapsMajority of flapsDonor site complicationsFree flap transferFree tissue transferReconstruction of headHospital stayPatient ageMain indicationsMinimal morbidityNeck burnsNecrosis rateAnterolateral thighHypertrophic scarringSecondary reconstructionRadial forearmFlap transferInfection rateLocal flapsCervicofacial burns