2023
Surgical management of breast fat necrosis: Multi-institutional data analysis of early outcomes and risk factors for complications
Knoedler S, Knoedler L, Patel H, Diatta F, Camacho J, Sofo G, Perozzo F, Evans B, Mookerjee V, Ayyala H, Pomahac B, Kauke-Navarro M. Surgical management of breast fat necrosis: Multi-institutional data analysis of early outcomes and risk factors for complications. Journal Of Plastic Reconstructive & Aesthetic Surgery 2023, 88: 292-295. PMID: 38029475, DOI: 10.1016/j.bjps.2023.11.015.Peer-Reviewed Original ResearchConceptsBreast fat necrosisChronic heart failureRisk factorsAdverse eventsHeart failureFemale patientsSurgical managementFat necrosisNational Surgical Quality Improvement ProgramSurgical Quality Improvement ProgramHigher wound classPostoperative adverse eventsNon-cancerous conditionsOutcomes of interestQuality Improvement ProgramMajority of casesPerioperative algorithmWound classComplication occurrenceComplication ratePostoperative outcomesSurgical complicationsMedical complicationsSurgical treatmentMultivariable analysisRates of National Institutes of Health Funding for Surgeon-Scientists, 1995-2020
Nguyen M, Gonzalez L, Newman A, Cannon A, Zarebski S, Chaudhry S, Pomahac B, Boatright D, Dardik A. Rates of National Institutes of Health Funding for Surgeon-Scientists, 1995-2020. JAMA Surgery 2023, 158: 756-764. PMID: 37195709, PMCID: PMC10193263, DOI: 10.1001/jamasurg.2023.1571.Peer-Reviewed Original ResearchConceptsHealth fundingNational InstituteNIH fundingCross-sectional studyDepartment of SurgeryGlobal disease burdenNumber of NIHNIH RePORTER databaseDisease burdenSurgical diseaseSurgical departmentPatient careResearch project grantsClinical settingSurgical subspecialtiesPhD scientistsSurgeryNIH grantsSubstantial disparitiesBoard certificationNIH investigatorsNIHClinical demandInvestigatorsProject grantsGender Disparity in National Institutes of Health Funding Among Surgeon-Scientists From 1995 to 2020
Nguyen M, Gonzalez L, Chaudhry S, Ahuja N, Pomahac B, Newman A, Cannon A, Zarebski S, Dardik A, Boatright D. Gender Disparity in National Institutes of Health Funding Among Surgeon-Scientists From 1995 to 2020. JAMA Network Open 2023, 6: e233630. PMID: 36939702, PMCID: PMC10028489, DOI: 10.1001/jamanetworkopen.2023.3630.Peer-Reviewed Original ResearchConceptsCross-sectional studyNIH fundingNational InstitutePatient-centered researchNIH RePORTER databaseWarrants further investigationPrincipal investigatorSurgical diseaseGlobal burdenMAIN OUTCOMEResearch project grantsSurgeonsWomenHealth fundingAcademic surgeonsMenNIH grantsDiseaseFurther investigationFacial Expression after Face Transplant: An International Face Transplant Cohort Comparison
Dorante M, Wang A, Kollar B, Perry B, Ertosun M, Lindford A, Kiukas E, Özkan Ö, Özkan Ö, Lassus P, Pomahac B. Facial Expression after Face Transplant: An International Face Transplant Cohort Comparison. Plastic & Reconstructive Surgery 2023, 152: 315e-325e. PMID: 36727808, DOI: 10.1097/prs.0000000000010242.Peer-Reviewed Original ResearchConceptsFT patientsHealthy controlsMotor function restorationMotor functionFace transplantFunction restorationAge-matched healthy controlsCLINICAL QUESTION/LEVELInterpositional nerve graftFull face transplantRespective healthy controlsMotor outcomeNerve coaptationFemale patientsNerve graftsPatientsPercentage restorationCohort comparisonFacial proceduresBilateral testsTransplantScore valuesFacial movements
2022
Perioperative Outcomes and Risk Profile of 4730 Cosmetic Breast Surgery Cases in Academic Institutions: An ACS-NSQIP Analysis
Knoedler S, Kauke-Navarro M, Haug V, Broer P, Pomahac B, Knoedler L, Panayi A. Perioperative Outcomes and Risk Profile of 4730 Cosmetic Breast Surgery Cases in Academic Institutions: An ACS-NSQIP Analysis. Aesthetic Surgery Journal 2022, 43: 433-451. PMID: 36472232, DOI: 10.1093/asj/sjac320.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseCosmetic breast surgeryObstructive pulmonary diseaseRisk factorsSurgical complicationsPulmonary diseaseSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseMulti-institutional national databaseMultiple proceduresQuality Improvement Program databaseImprovement Program databaseIndependent risk factorCongestive heart failurePositive safety profileObesity class 1ACS-NSQIP AnalysisAnesthesiology scoreBreast surgery casesPerioperative outcomesPerioperative protocolPostoperative outcomesClinical patternHeart failureFemale patients
2021
Immunoregulatory and lipid presentation pathways are upregulated in human face transplant rejection
Win T, Crisler W, Dyring-Andersen B, Lopdrup R, Teague J, Zhan Q, Barrera V, Sui S, Tasigiorgos S, Murakami N, Chandraker A, Tullius S, Pomahac B, Riella L, Clark R. Immunoregulatory and lipid presentation pathways are upregulated in human face transplant rejection. Journal Of Clinical Investigation 2021, 131 PMID: 33667197, PMCID: PMC8262560, DOI: 10.1172/jci135166.Peer-Reviewed Original ResearchConceptsVCA rejectionTransplant rejectionT cellsTissue injuryGene expression profilingAntigen-presenting cell activationT-cell receptor sequencingSolid organ transplantsCell receptor sequencingT cell activation pathwaysAntigen-specific activationProliferative T cellsCell activation pathwaysNovo Nordisk FoundationAmerican SocietyExpression profilingFace transplant patientsTransplant patientsImmunologic pathwaysImmunoregulatory networkSkin biopsiesImmunomodulatory pathwaysLimb transplantsLundbeck FoundationTransplant Research
2020
Indications for and Outcomes of Endoscopic Sinus Surgery and Other Rhinologic Surgery After Facial Transplant
Haug V, Yamasaki A, Fullerton Z, Maxfield A, Pomahac B, Bergmark R, Annino D. Indications for and Outcomes of Endoscopic Sinus Surgery and Other Rhinologic Surgery After Facial Transplant. JAMA Otolaryngology - Head & Neck Surgery 2020, 146: 669-671. PMID: 32525516, PMCID: PMC7290693, DOI: 10.1001/jamaoto.2020.0774.Peer-Reviewed Original ResearchRecognizing Emotional Expression as an Outcome Measure After Face Transplant
Dorante M, Kollar B, Obed D, Haug V, Fischer S, Pomahac B. Recognizing Emotional Expression as an Outcome Measure After Face Transplant. JAMA Network Open 2020, 3: e1919247. PMID: 31940037, PMCID: PMC6991259, DOI: 10.1001/jamanetworkopen.2019.19247.Peer-Reviewed Original Research
2019
Multidisciplinary Treatment to Restore Vision in Ocular Burns
Christensen J, Shanbhag S, Shih G, Goverman J, Pomahac B, Chodosh J, Ehrlichman R. Multidisciplinary Treatment to Restore Vision in Ocular Burns. Journal Of Burn Care & Research 2019, 41: 859-865. PMID: 31808803, DOI: 10.1093/jbcr/irz201.Peer-Reviewed Original ResearchConceptsSplit-thickness skin graftFull-thickness skin graftKeratoprosthesis placementSkin graftsCorneal blindnessLight perceptionBilateral corneal blindnessGood visual prognosisConsecutive burn patientsLoss of visionMucous membrane graftPeriorbital soft tissueVisual prognosisChart reviewCorneal scarringMultidisciplinary treatmentPostoperative visionInitial treatmentBurn patientsCorneal injuryCicatricial ectropionOcular burnsTear productionMembrane graftGlobe protectionTwenty-Four-Hour Ex Vivo Perfusion with Acellular Solution Enables Successful Replantation of Porcine Forelimbs.
Krezdorn N, Macleod F, Tasigiorgos S, Turk M D M, Wo L, Kiwanuka B A H, Lopdrup B I D R, Kollar B, Edelman E, Pomahac B. Twenty-Four-Hour Ex Vivo Perfusion with Acellular Solution Enables Successful Replantation of Porcine Forelimbs. Plastic & Reconstructive Surgery 2019, 144: 608e-618e. PMID: 31568296, DOI: 10.1097/prs.0000000000006084.Peer-Reviewed Original ResearchThe Evolving Clinical Presentation of Acute Rejection in Facial Transplantation
Haug V, Kollar B, Obed D, Kiwanuka H, Turk M, Wo L, Tasigiorgos S, Kueckelhaus M, Riella L, Pomahac B. The Evolving Clinical Presentation of Acute Rejection in Facial Transplantation. Facial Plastic Surgery & Aesthetic Medicine 2019, 21: 278-285. PMID: 30998810, PMCID: PMC6646986, DOI: 10.1001/jamafacial.2019.0076.Peer-Reviewed Original ResearchConceptsAcute rejectionSubtherapeutic tacrolimus levelsClinical signsRejection episodesImmunosuppressive therapySubclinical rejectionTacrolimus levelsMedical recordsOdds ratioFacial transplantationDiagnostic valueSignificant associationSingle-center cohort studyLate rejection episodesProtocol skin biopsiesSecond posttransplant yearSymptoms of rejectionTacrolimus blood levelsSecond postoperative yearReliable clinical signFull facial transplantationPostoperative yearPosttransplant yearYears posttransplantationAllograft rejection
2018
The Collagenase of the Bacterium Clostridium histolyticum in the Treatment of Irradiation-Induced Capsular Contracture
Diehm Y, Hirche C, Berger M, Heil J, Golatta M, Kotsougiani D, Pomahac B, Kneser U, Fischer S. The Collagenase of the Bacterium Clostridium histolyticum in the Treatment of Irradiation-Induced Capsular Contracture. Aesthetic Plastic Surgery 2018, 43: 836-844. PMID: 30456640, DOI: 10.1007/s00266-018-1267-y.Peer-Reviewed Original ResearchConceptsBacterium Clostridium histolyticumCapsular fibrosisHematoma formationTreatment optionsImplant pocketClostridium histolyticumSilicone implantsMiniature silicone implantsNovel treatment optionsPotential treatment optionInjection of collagenaseVessel wall architectureMethodsThirty-six ratsVessel wall thicknessCollagenase injectionSignificant complicationsBreast reconstructionCapsular contractureClinical safetyBreast cancerDay 1Application of collagenaseDay 120Implant sitesThin capsuleChronic rejection of human face allografts
Krezdorn N, Lian C, Wells M, Wo L, Tasigiorgos S, Xu S, Borges T, Frierson R, Stanek E, Riella L, Pomahac B, Murphy G. Chronic rejection of human face allografts. American Journal Of Transplantation 2018, 19: 1168-1177. PMID: 30312535, PMCID: PMC6433509, DOI: 10.1111/ajt.15143.Peer-Reviewed Original ResearchConceptsChronic rejectionComposite allograftsAutoimmune cutaneous disordersImmune-mediated changesLymphocyte-mediated cytotoxicityC-fosSevere facial disfigurementType IAcute rejectionSurveillance biopsiesIatrogenic immunosuppressionVascular ectasiaFollicular pluggingSystemic sclerosisHistopathologic evidenceClinical manifestationsPreventative therapyCutaneous disordersGraft durabilityFace allograftNasal mucosaPathologic changesPathologic alterationsEpidermal thinningSclerotic zoneIncreased levels of circulating MMP3 correlate with severe rejection in face transplantation
Kollar B, Shubin A, Borges T, Tasigiorgos S, Win T, Lian C, Dillon S, Gu X, Wyrobnik I, Murphy G, Pomahac B, Libermann T, Riella L. Increased levels of circulating MMP3 correlate with severe rejection in face transplantation. Scientific Reports 2018, 8: 14915. PMID: 30297859, PMCID: PMC6175842, DOI: 10.1038/s41598-018-33272-7.Peer-Reviewed Original ResearchConceptsSevere rejectionFace transplantationLarge independent patient cohortsAcute rejection episodesAnti-rejection treatmentFirst postoperative yearLongitudinal serum samplesNon-invasive candidate biomarkersViable treatment optionSOMAscan proteomics platformIndependent patient cohortsFace transplant recipientsRejection episodesPostoperative yearTransplant recipientsDevastating injuriesMMP3 levelsTransplant rejectionHistological gradePatient cohortTreatment optionsSurrogate markerMMP3 proteinCandidate biomarkersTransplantationSoftware‐based video analysis of functional outcomes of face transplantation
Fischer S, Diehm Y, Dorante M, Kotsougiani D, Kueckelhaus M, Alhefzi M, Bueno E, Pomahac B. Software‐based video analysis of functional outcomes of face transplantation. Microsurgery 2018, 39: 53-61. PMID: 30159931, DOI: 10.1002/micr.30360.Peer-Reviewed Original ResearchConceptsFace transplantationNormal populationAssessment of outcomesDifferent time pointsFunctional outcomeFacial movementsPatient's abilitySame patientTransplantationMouth openingOutcome assessmentPatientsValuable assessment toolOpen mouthEye closureTime pointsRetrospective assessmentMonthsLip purseFacial transplantationAssessment toolSound evidenceOutcomesNoseEyebrowsReduced Hypoxia-Related Genes in Porcine Limbs in Ex Vivo Hypothermic Perfusion Versus Cold Storage
Krezdorn N, Sakthivel D, Turk M, Aycart M, Tasigiorgos S, Bueno E, Sinha I, Pomahac B. Reduced Hypoxia-Related Genes in Porcine Limbs in Ex Vivo Hypothermic Perfusion Versus Cold Storage. Journal Of Surgical Research 2018, 232: 137-145. PMID: 30463709, DOI: 10.1016/j.jss.2018.05.067.Peer-Reviewed Original ResearchConceptsStatic cold storagePerfusion groupIschemia-reperfusion injuryPCR gene arrayPorcine limbsMuscle fiber disruptionIschemic injuryPerfadex solutionPerfused limbMachine perfusionHypothermic perfusionHistological changesPreservation modalityMuscle biopsyLimb replantationPerfusionICE groupLess activationPorcine forelimbDownregulation of genesMolecular changesLimbFiber disruptionExpression levelsReplantationQuality of Life and Psychosocial Functioning 2 Years Following Facial Transplantation
Oser M, Nizzi M, Zinser J, Turk M, Epstein R, Bueno E, Gitlin D, Pomahac B. Quality of Life and Psychosocial Functioning 2 Years Following Facial Transplantation. Journal Of The Academy Of Consultation-Liaison Psychiatry 2018, 59: 591-600. PMID: 29861176, DOI: 10.1016/j.psym.2018.04.005.Peer-Reviewed Original ResearchConceptsPhysical health QoLDepressive symptomsHealth statusPhysical health-related QoLFace transplantationOverall depressive symptomsHealth-related QoLMental health QOLSubthreshold depressive symptomsSevere facial disfigurementFacial transplantationQuality of lifeImmunosuppression inductionMonths posttransplantationDepressive episodePhysical QoLHigh health statusPatientsTransplantationQoLPsychosocial functioningLife outcomesCeiling effectsFacial disfigurementSymptomsFacial restoration by transplantation
Kollar B, Pomahac B. Facial restoration by transplantation. The Surgeon 2018, 16: 245-249. PMID: 29490887, DOI: 10.1016/j.surge.2018.01.003.Peer-Reviewed Original ResearchConceptsWorld War I.World War IIModern plastic surgerySir Harold GilliesPeter Bent Brigham HospitalWar IIFace transplantationFirst successful kidney transplantationJoseph MurraySuccessful kidney transplantationNobel PrizeWorldFacial restorationKidney transplantationTransplant cohortUnique patientsWomen's HospitalSkin graftsOrgan transplantationTransplantationHospitalPlastic surgeonsPlastic surgerySoldiersBattlefield
2017
Long-Term Social Reintegration Outcomes for Burn Survivors With and Without Peer Support Attendance: A Life Impact Burn Recovery Evaluation (LIBRE) Study
Grieve B, Shapiro G, Wibbenmeyer L, Acton A, Lee A, Marino M, Jette A, Schneider J, Kazis L, Ryan C, Board L, Badger K, Cancio L, Carrougher G, Carson J, Carter D, Chang P, Deeter L, Edorf F, Fagin A, Faoro N, Faucher L, Fauerbach J, Fidler P, Foster K, Friedstat J, Gibran N, Goverman J, Harrington D, Herndon D, Hickerson W, Holavanahalli R, Houng A, Hwang J, Jeng J, Joe V, Kopari N, Kowalske K, Lee R, Levi B, Liu Y, Palmieri T, Pomahač B, Reilly D, Romanowski K, Schulz J, Sheridan R, Shupp J, Sinha I, Travis T, Wibbenmeyer L. Long-Term Social Reintegration Outcomes for Burn Survivors With and Without Peer Support Attendance: A Life Impact Burn Recovery Evaluation (LIBRE) Study. Archives Of Physical Medicine And Rehabilitation 2017, 101: s92-s98. PMID: 29097179, PMCID: PMC9201552, DOI: 10.1016/j.apmr.2017.10.007.Peer-Reviewed Original ResearchConceptsTotal body surface areaSupport group attendanceBurn survivorsGroup attendanceLarger burn sizeSupport groupsBody surface areaCross-sectional studyLife Impact Burn Recovery Evaluation (LIBRE) StudyFuture intervention studiesCross-sectional surveyPeer support groupsBurn sizeLife Impact Burn Recovery Evaluation ProfileSocial interaction scoresExperience With Patient Referrals for Upper Extremity Transplantation at a U.S. Academic Medical Center
Kiwanuka H, Aycart M, Bueno E, Pomahac B, Talbot S. Experience With Patient Referrals for Upper Extremity Transplantation at a U.S. Academic Medical Center. The Journal Of Hand Surgery 2017, 42: 751.e1-751.e6. PMID: 28648330, DOI: 10.1016/j.jhsa.2017.05.016.Peer-Reviewed Original ResearchConceptsUpper extremity transplantationMode of referralPhysician referralExtremity transplantationDemographic dataSelf-referred individualsSTUDY/LEVELInjury-related characteristicsPopulation of patientsU.S. academic medical centersUpper extremity disabilityClinical trial outcomesFisher's exact testAcademic medical centerChi-square testCommon indicationInjury characteristicsReferral patternsPatient referralTreatment modalitiesExtremity disabilityScreening practicesInstitutional experienceImmediate exclusionLevel IV