2017
Acellular Hypothermic Extracorporeal Perfusion Extends Allowable Ischemia Time in a Porcine Whole Limb Replantation Model
Kueckelhaus M, Dermietzel A, Alhefzi M, Aycart M, Fischer S, Krezdorn N, Wo L, Maarouf O, Riella L, Abdi R, Bueno E, Pomahac B. Acellular Hypothermic Extracorporeal Perfusion Extends Allowable Ischemia Time in a Porcine Whole Limb Replantation Model. Plastic & Reconstructive Surgery 2017, 139: 922e-932e. PMID: 28350667, DOI: 10.1097/prs.0000000000003208.Peer-Reviewed Original Research
2016
Long-Term Effects of the Collagenase of the Bacterium Clostridium histolyticum for the Treatment of Capsular Fibrosis After Silicone Implants
Fischer S, Diehm Y, Henzler T, Berger M, Kolbenschlag J, Latz A, Bueno E, Hirche C, Kneser U, Pomahac B. Long-Term Effects of the Collagenase of the Bacterium Clostridium histolyticum for the Treatment of Capsular Fibrosis After Silicone Implants. Aesthetic Plastic Surgery 2016, 41: 211-220. PMID: 28008464, DOI: 10.1007/s00266-016-0724-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiopsy, NeedleBreast ImplantationBreast ImplantsClostridium histolyticumDisease Models, AnimalFemaleFibrosisHumansImmunohistochemistryImplant Capsular ContractureInjections, IntralesionalMagnetic Resonance ImagingMicrobial CollagenasePregnancyRandom AllocationRatsRats, Inbred LewReal-Time Polymerase Chain ReactionReference ValuesSilicone GelsTreatment OutcomeUltrasonography, DopplerConceptsMagnetic resonance imagingBacterium Clostridium histolyticumSilicone implantsCapsular fibrosisCollagenase injectionTreatment groupsSkin perforationFrequent long-term complicationMethodsForty-eight ratsMiniature silicone implantsLong-term complicationsClostridium histolyticumViable treatment optionLevel of evidenceHigh-resolution ultrasoundCapsule thicknessInjection of collagenaseExpression levelsDays post injectionLevel AssignedThis journalLong-term effectivenessBackgroundCapsular contractureAnti-fibrotic genesTreatment optionsImplant pocket
2015
The Collagenase of the Bacterium Clostridium histolyticum for the Treatment of Capsular Fibrosis after Silicone Implants
Fischer S, Hirsch T, Diehm Y, Kiefer J, Bueno E, Kueckelhaus M, Kremer T, Hirche C, Kneser U, Pomahac B. The Collagenase of the Bacterium Clostridium histolyticum for the Treatment of Capsular Fibrosis after Silicone Implants. Plastic & Reconstructive Surgery 2015, 136: 981-989. PMID: 26171751, DOI: 10.1097/prs.0000000000001698.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiopsy, NeedleBreast ImplantsClostridium histolyticumDisease Models, AnimalFemaleFibrosisImmunohistochemistryImplant Capsular ContractureMagnetic Resonance ImagingMicrobial CollagenaseRandom AllocationRatsReal-Time Polymerase Chain ReactionReference ValuesSilicone GelsTreatment OutcomeConceptsBacterium Clostridium histolyticumSilicone implantsSkin perforationFibrotic capsuleMiniature silicone implantsClostridium histolyticumMagnetic resonance imagingInflammatory markersDosage-dependent decreasePolymerase chain reaction analysisCapsular fibrosisSafe clinical applicationCapsular contractureDupuytren's contractureMechanical irritationChain reaction analysisControl groupDrug AdministrationResonance imagingHistologic measurementsU.S. FoodThin capsuleVivo studiesSkin digestionCollagen densitySilicone Implants with Smooth Surfaces Induce Thinner but Denser Fibrotic Capsules Compared to Those with Textured Surfaces in a Rodent Model
Fischer S, Hirche C, Reichenberger M, Kiefer J, Diehm Y, Mukundan S, Alhefzi M, Bueno E, Kneser U, Pomahac B. Silicone Implants with Smooth Surfaces Induce Thinner but Denser Fibrotic Capsules Compared to Those with Textured Surfaces in a Rodent Model. PLOS ONE 2015, 10: e0132131. PMID: 26151888, PMCID: PMC4495016, DOI: 10.1371/journal.pone.0132131.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticBreast DiseasesBreast ImplantationBreast ImplantsCollagen Type IDisease Models, AnimalFemaleFibrosisGene ExpressionHumansImplant Capsular ContractureMagnetic Resonance ImagingMammaplastyRadiographyRats, Inbred LewReverse Transcriptase Polymerase Chain ReactionSilicone GelsSurface PropertiesUltrasonography