Predictors for Major Wound Complications Following Preoperative Radiotherapy and Surgery for Soft-Tissue Sarcoma of the Extremities and Trunk: Importance of Tumor Proximity to Skin Surface
Baldini E, Lapidus M, Wang Q, Manola J, Orgill D, Pomahac B, Marcus K, Bertagnolli M, Devlin P, George S, Abraham J, Ferrone M, Ready J, Raut C. Predictors for Major Wound Complications Following Preoperative Radiotherapy and Surgery for Soft-Tissue Sarcoma of the Extremities and Trunk: Importance of Tumor Proximity to Skin Surface. Annals Of Surgical Oncology 2012, 20: 1494-1499. PMID: 23242820, DOI: 10.1245/s10434-012-2797-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overDiabetes ComplicationsDisease-Free SurvivalFemaleHumansLower ExtremityMaleMiddle AgedNeoadjuvant TherapyNeoplasm Recurrence, LocalPostoperative ComplicationsRadiotherapy, AdjuvantSarcomaSkinSkin TransplantationSoft Tissue NeoplasmsSurgical FlapsTorsoUpper ExtremityWound HealingYoung AdultConceptsMajor wound complicationsSoft tissue sarcomasSplit-thickness skin graftPreoperative radiotherapyWound complicationsPostoperative radiotherapyMultivariable analysisTumor proximityExact testResultsMedian tumor sizeSimilar local controlOverall survival rateLong-term fibrosisSignificant predictorsFisher's exact testHigh rateNonoperative managementIndependent predictorsRadical resectionTumor sizeSkin surfaceUnivariate analysisSkin graftsComplicationsLocal control