2022
mTORC1 Inhibition Protects Human Regulatory T Cells From Granzyme-B-Induced Apoptosis
Eskandari SK, Allos H, Al Dulaijan B, Melhem G, Sulkaj I, Alhaddad JB, Saad AJ, Deban C, Chu P, Choi JY, Kollar B, Pomahac B, Riella LV, Berger SP, Sanders JSF, Lieberman J, Li L, Azzi JR. mTORC1 Inhibition Protects Human Regulatory T Cells From Granzyme-B-Induced Apoptosis. Frontiers In Immunology 2022, 13: 899975. PMID: 35757726, PMCID: PMC9229986, DOI: 10.3389/fimmu.2022.899975.Peer-Reviewed Original ResearchConceptsRegulatory T cellsT cellsHuman regulatory T cellsHost THumanized mouse modelPro-apoptotic pathwaysSkin allotransplantationClinical efficacyImmunosuppressive potencyIntracytoplasmic expressionTransplant fieldMouse modelCellular therapyHigh expressionTarget cellsRapamycin complex 1Lysosomal granulesFunctional effectsMechanistic targetPatientsApoptosisC-JunGranzymesDrug targetsS6K
1999
Dermatan sulfate activates nuclear factor-κb and induces endothelial and circulating intercellular adhesion molecule-1
Penc S, Pomahac B, Eriksson E, Detmar M, Gallo R. Dermatan sulfate activates nuclear factor-κb and induces endothelial and circulating intercellular adhesion molecule-1. Journal Of Clinical Investigation 1999, 103: 1329-1335. PMID: 10225976, PMCID: PMC408352, DOI: 10.1172/jci4742.Peer-Reviewed Original ResearchConceptsICAM-1Effect of DSDermatan sulfateCell surface ICAM-1Intercellular adhesion molecule-1Endothelial cellsCultured human dermal microvascular endothelial cellsIntercellular adhesion molecule-1 mRNAIL-1 releaseAdhesion molecule-1Surface ICAM-1Human dermal microvascular endothelial cellsDermal microvascular endothelial cellsMicrovascular endothelial cellsNF-kappaB activationNuclear factor-kappaBTNF-alphaInflammatory phaseMolecule-1Chondroitin sulfate BFactor-kappaBSoluble ICAMChondroitin sulfate ANF-kappaBPhysiologic concentrations