2018
The Collagenase of the Bacterium Clostridium histolyticum in the Treatment of Irradiation-Induced Capsular Contracture
Diehm Y, Hirche C, Berger M, Heil J, Golatta M, Kotsougiani D, Pomahac B, Kneser U, Fischer S. The Collagenase of the Bacterium Clostridium histolyticum in the Treatment of Irradiation-Induced Capsular Contracture. Aesthetic Plastic Surgery 2018, 43: 836-844. PMID: 30456640, DOI: 10.1007/s00266-018-1267-y.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBreast ImplantsClostridium histolyticumCollagenasesFemaleImplant Capsular ContractureRadiation InjuriesRatsRats, Inbred LewConceptsBacterium Clostridium histolyticumCapsular fibrosisHematoma formationTreatment optionsImplant pocketClostridium histolyticumSilicone implantsMiniature silicone implantsNovel treatment optionsPotential treatment optionInjection of collagenaseVessel wall architectureMethodsThirty-six ratsVessel wall thicknessCollagenase injectionSignificant complicationsBreast reconstructionCapsular contractureClinical safetyBreast cancerDay 1Application of collagenaseDay 120Implant sitesThin capsule
2016
Long-Term Effects of the Collagenase of the Bacterium Clostridium histolyticum for the Treatment of Capsular Fibrosis After Silicone Implants
Fischer S, Diehm Y, Henzler T, Berger M, Kolbenschlag J, Latz A, Bueno E, Hirche C, Kneser U, Pomahac B. Long-Term Effects of the Collagenase of the Bacterium Clostridium histolyticum for the Treatment of Capsular Fibrosis After Silicone Implants. Aesthetic Plastic Surgery 2016, 41: 211-220. PMID: 28008464, DOI: 10.1007/s00266-016-0724-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiopsy, NeedleBreast ImplantationBreast ImplantsClostridium histolyticumDisease Models, AnimalFemaleFibrosisHumansImmunohistochemistryImplant Capsular ContractureInjections, IntralesionalMagnetic Resonance ImagingMicrobial CollagenasePregnancyRandom AllocationRatsRats, Inbred LewReal-Time Polymerase Chain ReactionReference ValuesSilicone GelsTreatment OutcomeUltrasonography, DopplerConceptsMagnetic resonance imagingBacterium Clostridium histolyticumSilicone implantsCapsular fibrosisCollagenase injectionTreatment groupsSkin perforationFrequent long-term complicationMethodsForty-eight ratsMiniature silicone implantsLong-term complicationsClostridium histolyticumViable treatment optionLevel of evidenceHigh-resolution ultrasoundCapsule thicknessInjection of collagenaseExpression levelsDays post injectionLevel AssignedThis journalLong-term effectivenessBackgroundCapsular contractureAnti-fibrotic genesTreatment optionsImplant pocket
2015
Silicone Implants with Smooth Surfaces Induce Thinner but Denser Fibrotic Capsules Compared to Those with Textured Surfaces in a Rodent Model
Fischer S, Hirche C, Reichenberger M, Kiefer J, Diehm Y, Mukundan S, Alhefzi M, Bueno E, Kneser U, Pomahac B. Silicone Implants with Smooth Surfaces Induce Thinner but Denser Fibrotic Capsules Compared to Those with Textured Surfaces in a Rodent Model. PLOS ONE 2015, 10: e0132131. PMID: 26151888, PMCID: PMC4495016, DOI: 10.1371/journal.pone.0132131.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticBreast DiseasesBreast ImplantationBreast ImplantsCollagen Type IDisease Models, AnimalFemaleFibrosisGene ExpressionHumansImplant Capsular ContractureMagnetic Resonance ImagingMammaplastyRadiographyRats, Inbred LewReverse Transcriptase Polymerase Chain ReactionSilicone GelsSurface PropertiesUltrasonography