Chronic rejection of human face allografts
Krezdorn N, Lian C, Wells M, Wo L, Tasigiorgos S, Xu S, Borges T, Frierson R, Stanek E, Riella L, Pomahac B, Murphy G. Chronic rejection of human face allografts. American Journal Of Transplantation 2018, 19: 1168-1177. PMID: 30312535, PMCID: PMC6433509, DOI: 10.1111/ajt.15143.Peer-Reviewed Original ResearchConceptsChronic rejectionComposite allograftsAutoimmune cutaneous disordersImmune-mediated changesLymphocyte-mediated cytotoxicityC-fosSevere facial disfigurementType IAcute rejectionSurveillance biopsiesIatrogenic immunosuppressionVascular ectasiaFollicular pluggingSystemic sclerosisHistopathologic evidenceClinical manifestationsPreventative therapyCutaneous disordersGraft durabilityFace allograftNasal mucosaPathologic changesPathologic alterationsEpidermal thinningSclerotic zone