2024
Cellular therapeutics and immunotherapies in wound healing – on the pulse of time?
Huelsboemer L, Knoedler L, Kochen A, Yu C, Hosseini H, Hollmann K, Choi A, Stögner V, Knoedler S, Hsia H, Pomahac B, Kauke-Navarro M. Cellular therapeutics and immunotherapies in wound healing – on the pulse of time? Military Medical Research 2024, 11: 23. PMID: 38637905, PMCID: PMC11025282, DOI: 10.1186/s40779-024-00528-5.Peer-Reviewed Original ResearchConceptsStandard of careChronic wound healing disordersLocal wound irrigationWound healingChronic inflammatory microenvironmentFree flap techniqueWound healing disordersChronic woundsGenetic risk profilesPhysiological wound healingAdequate blood supplySurgical debridementFlap techniqueCellular therapyCurrent therapiesHealing disordersInflammatory microenvironmentWound irrigationNon-healing woundsCellular therapeuticsGeneral anesthesiaFormation of biofilmsWound debridementSkin graftsImmunotherapy
2019
Multidisciplinary Treatment to Restore Vision in Ocular Burns
Christensen J, Shanbhag S, Shih G, Goverman J, Pomahac B, Chodosh J, Ehrlichman R. Multidisciplinary Treatment to Restore Vision in Ocular Burns. Journal Of Burn Care & Research 2019, 41: 859-865. PMID: 31808803, DOI: 10.1093/jbcr/irz201.Peer-Reviewed Original ResearchConceptsSplit-thickness skin graftFull-thickness skin graftKeratoprosthesis placementSkin graftsCorneal blindnessLight perceptionBilateral corneal blindnessGood visual prognosisConsecutive burn patientsLoss of visionMucous membrane graftPeriorbital soft tissueVisual prognosisChart reviewCorneal scarringMultidisciplinary treatmentPostoperative visionInitial treatmentBurn patientsCorneal injuryCicatricial ectropionOcular burnsTear productionMembrane graftGlobe protection
2018
Cutaneous Breast Radiation-associated Angiosarcoma
Mella J, Ross K, Li G, Pomahac B, Raut C, Orgill D. Cutaneous Breast Radiation-associated Angiosarcoma. Plastic & Reconstructive Surgery Global Open 2018, 6: e1938. PMID: 30349797, PMCID: PMC6191213, DOI: 10.1097/gox.0000000000001938.Peer-Reviewed Original ResearchRadiation-associated angiosarcomaAbdominal advancement flapOperative timeOmental flapSkin graftsAdvancement flapPedicled latissimus dorsiAverage operative timeLength of staySplit-thickness skinLatissimus dorsi muscleSoft tissue defectsPectoralis major muscleReconstructive experienceBreast radiationRare complicationComplication rateRetrospective reviewMedian lengthBreast irradiationBreast reconstructionImmediate reconstructionIrradiated skinReconstruction flapReconstructive optionsFacial restoration by transplantation
Kollar B, Pomahac B. Facial restoration by transplantation. The Surgeon 2018, 16: 245-249. PMID: 29490887, DOI: 10.1016/j.surge.2018.01.003.Peer-Reviewed Original ResearchConceptsWorld War I.World War IIModern plastic surgerySir Harold GilliesPeter Bent Brigham HospitalWar IIFace transplantationFirst successful kidney transplantationJoseph MurraySuccessful kidney transplantationNobel PrizeWorldFacial restorationKidney transplantationTransplant cohortUnique patientsWomen's HospitalSkin graftsOrgan transplantationTransplantationHospitalPlastic surgeonsPlastic surgerySoldiersBattlefield
2016
Efficacy and Safety of the Collagenase of the Bacterium Clostridium Histolyticum for the Treatment of Capsular Contracture after Silicone Implants: Ex-Vivo Study on Human Tissue
Fischer S, Hirche C, Diehm Y, Nuutila K, Kiefer J, Gazyakan E, Bueno E, Kremer T, Kneser U, Pomahac B. Efficacy and Safety of the Collagenase of the Bacterium Clostridium Histolyticum for the Treatment of Capsular Contracture after Silicone Implants: Ex-Vivo Study on Human Tissue. PLOS ONE 2016, 11: e0156428. PMID: 27232716, PMCID: PMC4883774, DOI: 10.1371/journal.pone.0156428.Peer-Reviewed Original ResearchConceptsFull-thickness skin graftThickness skin graftBacterium Clostridium histolyticumCapsular contractureSkin graftsBreast sitesSilicone implantsReasonable treatment optionClostridium histolyticumFibrotic capsuleCollagen subtypesEx vivo studyCollagenase doseEx-vivo settingTreatment optionsContracture tissueAcellular tissue matrixOutcome measuresHistological assessmentSubtype 4Capsule tissueClinical utilizationDifferent dosesClinical realityType 4
2012
Predictors for Major Wound Complications Following Preoperative Radiotherapy and Surgery for Soft-Tissue Sarcoma of the Extremities and Trunk: Importance of Tumor Proximity to Skin Surface
Baldini E, Lapidus M, Wang Q, Manola J, Orgill D, Pomahac B, Marcus K, Bertagnolli M, Devlin P, George S, Abraham J, Ferrone M, Ready J, Raut C. Predictors for Major Wound Complications Following Preoperative Radiotherapy and Surgery for Soft-Tissue Sarcoma of the Extremities and Trunk: Importance of Tumor Proximity to Skin Surface. Annals Of Surgical Oncology 2012, 20: 1494-1499. PMID: 23242820, DOI: 10.1245/s10434-012-2797-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overDiabetes ComplicationsDisease-Free SurvivalFemaleHumansLower ExtremityMaleMiddle AgedNeoadjuvant TherapyNeoplasm Recurrence, LocalPostoperative ComplicationsRadiotherapy, AdjuvantSarcomaSkinSkin TransplantationSoft Tissue NeoplasmsSurgical FlapsTorsoUpper ExtremityWound HealingYoung AdultConceptsMajor wound complicationsSoft tissue sarcomasSplit-thickness skin graftPreoperative radiotherapyWound complicationsPostoperative radiotherapyMultivariable analysisTumor proximityExact testResultsMedian tumor sizeSimilar local controlOverall survival rateLong-term fibrosisSignificant predictorsFisher's exact testHigh rateNonoperative managementIndependent predictorsRadical resectionTumor sizeSkin surfaceUnivariate analysisSkin graftsComplicationsLocal controlEpidermal Regeneration by Micrograft Transplantation with Immediate 100-Fold Expansion
Hackl F, Bergmann J, Granter S, Koyama T, Kiwanuka E, Zuhaili B, Pomahac B, Caterson E, Junker J, Eriksson E. Epidermal Regeneration by Micrograft Transplantation with Immediate 100-Fold Expansion. Plastic & Reconstructive Surgery 2012, 129: 443e-452e. PMID: 22373992, DOI: 10.1097/prs.0b013e318241289c.Peer-Reviewed Original ResearchConceptsSplit-thickness skin graftSkin graftsDermal sideEarly clinical resultsCorresponding time pointsFull-thickness woundsMicrograft transplantationDiabetic pigsClinical resultsMajor burnsCurrent treatmentSkin micrograftsComplete epithelializationDiabetic woundsWound chambersPercent reepithelializationGraftChronic woundsHealthy pigsTime pointsWound repairWoundsTransplantationMicrograftsEpidermal regeneration
2010
Meshed Skin Grafts Placed Upside Down Can Take If Desiccation Is Prevented
Zuhaili B, Aflaki P, Koyama T, Fossum M, Reish R, Schmidt B, Pomahac B, Eriksson E. Meshed Skin Grafts Placed Upside Down Can Take If Desiccation Is Prevented. Plastic & Reconstructive Surgery 2010, 125: 855-865. PMID: 20195112, PMCID: PMC2848958, DOI: 10.1097/prs.0b013e3181ccdc42.Peer-Reviewed Original ResearchConceptsSkin graftsMeshed graftReepithelialization rateSplit-thickness skin graftMeshed skin graftAutologous split-thickness skin graftWound environmentFull-thickness woundsHistologic specimensAccelerated reepithelializationDay 4GraftHigh contraction rateWound contractionSheet graftsWound healingWoundsYorkshire pigsSignificant differencesSurvivalHealingRegular graftsReepithelializationContraction rateCurrent study
2006
Fourth-Degree Burns to the Lower Extremity with Exposed Tendon and Bone: A Ten-Year Experience
Parrett B, Pomahac B, Demling R, Orgill D. Fourth-Degree Burns to the Lower Extremity with Exposed Tendon and Bone: A Ten-Year Experience. Journal Of Burn Care & Research 2006, 27: 34-39. PMID: 16566535, DOI: 10.1097/01.bcr.0000192265.20514.c5.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAmputation, SurgicalAtmospheric PressureBacteremiaBurn UnitsBurnsCellulitisDebridementFemaleGranulation TissueHumansLength of StayLimb SalvageLower ExtremityMaleMiddle AgedRetrospective StudiesSurgical FlapsTreatment OutcomeUrban Health ServicesVacuumVenous ThrombosisWound HealingConceptsLower extremity burnsLimb salvageBurn sizeMultistage reconstructive proceduresMean hospital stayDeep vein thrombosisMultiple skin graftsSignificant functional impairmentTen-year experienceUrban burn centerFree tissue transferFourth-degree burnsMajority of casesHospital stayVein thrombosisMean ageFillet flapBurn centerFunctional impairmentLower extremitiesSkin graftsExtremity burnsFlap closureReconstructive proceduresLimb amputation
2002
Autologous Skin Transplantation: Comparison of Minced Skin to Other Techniques
Svensjö T, Pomahac B, Yao F, Slama J, Wasif N, Eriksson E. Autologous Skin Transplantation: Comparison of Minced Skin to Other Techniques. Journal Of Surgical Research 2002, 103: 19-29. PMID: 11855913, DOI: 10.1006/jsre.2001.6331.Peer-Reviewed Original Research
1998
Tissue Engineering of Skin
Pomahač B, Svensjö T, Yao F, Brown H, Eriksson E. Tissue Engineering of Skin. Journal Of Dental Research 1998, 9: 333-344. PMID: 9715370, DOI: 10.1177/10454411980090030601.Peer-Reviewed Original Research