2024
The impact of age on outcomes after breast reduction surgery – A multi-institutional data analysis of 40,958 cases
Knoedler S, Perozzo F, Jiang J, Kosyk M, Alfertshofer M, Schenck T, Kern B, Sofo G, Knoedler L, Panayi A, Pomahac B, Kauke-Navarro M, Kim B. The impact of age on outcomes after breast reduction surgery – A multi-institutional data analysis of 40,958 cases. Journal Of Plastic Reconstructive & Aesthetic Surgery 2024, 98: 318-330. PMID: 39321535, DOI: 10.1016/j.bjps.2024.09.027.Peer-Reviewed Original ResearchReduction mammoplastyFemale patientsMedical complicationsImpact of ageAmerican College of Surgeons National Surgical Quality Improvement ProgramSurgeons National Surgical Quality Improvement ProgramNational Surgical Quality Improvement ProgramSurgical Quality Improvement ProgramPatients aged <Patients aged >Breast reduction surgeryAdult female patientsQuality Improvement ProgramPostoperative morbiditySurgical complicationsPostoperative outcomesPatient ageReduction surgeryDeterminants of riskMultivariate analysisAmerican CollegeComplicationsLow riskPatientsMammoplastyRobotic-Assisted Microsurgery in Lymphatic Reconstruction.
Stögner V, Pucciarelli D, Pomahac B, Ayyala H. Robotic-Assisted Microsurgery in Lymphatic Reconstruction. Journal Of Craniofacial Surgery 2024 PMID: 39283135, DOI: 10.1097/scs.0000000000010608.Peer-Reviewed Original ResearchLymphatic reconstructionRobotic-assisted microsurgeryBreast cancer-related lymphedemaCancer-related lymphedemaSurgical outcomesYears of clinical experienceMicrosurgical reconstructionPatient groupLymphatic flowCancer incidenceSurvival rateLymphatic anastomosisMicrosurgical performanceClinical experienceMicrosurgeryLower extremitiesHuman vesselsLymphatic microsurgeryPatientsMicrosurgical robotPhysiological tremor
2023
The significance of timing in breast reconstruction after mastectomy: An ACS-NSQIP analysis
Knoedler S, Kauke-Navarro M, Knoedler L, Friedrich S, Ayyala H, Haug V, Didzun O, Hundeshagen G, Bigdeli A, Kneser U, Machens H, Pomahac B, Orgill D, Broer P, Panayi A. The significance of timing in breast reconstruction after mastectomy: An ACS-NSQIP analysis. Journal Of Plastic Reconstructive & Aesthetic Surgery 2023, 89: 40-50. PMID: 38134626, DOI: 10.1016/j.bjps.2023.11.049.Peer-Reviewed Original ResearchImmediate BRTime pointsACS-NSQIP databaseLow complication rateACS-NSQIP AnalysisBreast cancer patientsBreast reconstruction optionsAutologous cohortsComplication rateSignificance of timingFemale patientsMedical complicationsMultivariable analysisMore complicationsPatient eligibilityCancer patientsBreast reconstructionOncological purposesPatientsComplicationsReconstruction optionsPropensity scoreCase workupMastectomyEligibilityApplication possibilities of artificial intelligence in facial vascularized composite allotransplantation—a narrative review
Knoedler L, Knoedler S, Allam O, Remy K, Miragall M, Safi A, Alfertshofer M, Pomahac B, Kauke-Navarro M. Application possibilities of artificial intelligence in facial vascularized composite allotransplantation—a narrative review. Frontiers In Surgery 2023, 10: 1266399. PMID: 38026484, PMCID: PMC10646214, DOI: 10.3389/fsurg.2023.1266399.Peer-Reviewed Original ResearchComposite allotransplantationLong-term outcomesFacial trauma patientsSevere facial disfigurementRejection episodesSurgical treatmentTrauma patientsMalignancy screeningReconstructive surgeryClinical challengeFacial traumaPaucity of studiesReconstructive strategiesNarrative reviewPatientsFacial disfigurementAllotransplantationFuture studiesSurgeryDiagnosisTraumaDisfigurementVascularized Composite Allograft Versus Prosthetic for Reconstruction After Facial and Hand Trauma
Noel O, Dumbrava M, Daoud D, Kammien A, Kauke-Navarro M, Pomahac B, Colen D. Vascularized Composite Allograft Versus Prosthetic for Reconstruction After Facial and Hand Trauma. Annals Of Plastic Surgery 2023, 92: 100-105. PMID: 37962243, DOI: 10.1097/sap.0000000000003731.Peer-Reviewed Original ResearchConceptsHand traumaHand/upper extremityLong-term outcomesUpper extremity traumaDifferent reconstructive optionsUse of prosthesesExtremity traumaBenefit profileUpper extremityReconstructive optionsComposite allotransplantationFace traumaHand reconstructionTraumaClinical realityPrimary optionProsthesisPatientsVCASLAM-based Surgical Guidance For Breast Reconstruction Surgery
Fu E, Alarcón de la Lastra Á, Zhou H, Zhang R, Broyles J, Ayyala H, Pomahac B, Jayender J. SLAM-based Surgical Guidance For Breast Reconstruction Surgery. 2023, 1-2. DOI: 10.31256/hsmr2023.1.Peer-Reviewed Original ResearchSingle Stitch Vicryl Mesh Wrap for Prepectoral Implant Breast Reconstruction
Mookerjee V, Stögner V, Alper D, Evans B, Pomahac B. Single Stitch Vicryl Mesh Wrap for Prepectoral Implant Breast Reconstruction. Plastic & Reconstructive Surgery Global Open 2023, 11: e5058. PMID: 37313479, PMCID: PMC10259646, DOI: 10.1097/gox.0000000000005058.Peer-Reviewed Original ResearchPrepectoral breast reconstructionAcellular dermal matrixBreast reconstructionPrepectoral reconstructionVicryl meshDermal matrixAcellular dermal matrix groupOverall complication rateImplant breast reconstructionConventional reconstructive techniquesComplication ratePatient demographicsRetrospective reviewOperative timeImplant coverageSingle institutionTacking suturesMesh wrapVicryl groupSafe techniqueReconstructive techniquesSeparate cohortPatientsBreastComplicationsThe surgical patient of yesterday, today, and tomorrow—a time-trend analysis based on a cohort of 8.7 million surgical patients
Knoedler S, Matar D, Friedrich S, Knoedler L, Haug V, Hundeshagen G, Kauke-Navarro M, Kneser U, Pomahac B, Orgill D, Panayi A. The surgical patient of yesterday, today, and tomorrow—a time-trend analysis based on a cohort of 8.7 million surgical patients. International Journal Of Surgery 2023, 109: 2631-2640. PMID: 37788019, PMCID: PMC10498871, DOI: 10.1097/js9.0000000000000511.Peer-Reviewed Original ResearchConceptsSurgical patientsMedian ageMedian BMISurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseQuality Improvement Program databaseACS-NSQIP databaseImprovement Program databaseObesity class IProportion of patientsCohort of patientsPrevalence of diabetesType 2 diabetesGlobal healthcare deliveryFuture surgical careField of surgeryTime trend analysisPatient ageSurgical cohortDiabetes prevalenceProgram databaseSurgical careAmerican CollegeGeneral populationPatientsCellular activation pathways and interaction networks in vascularized composite allotransplantation
Knoedler L, Knoedler S, Panayi A, Lee C, Sadigh S, Huelsboemer L, Stoegner V, Schroeter A, Kern B, Mookerjee V, Lian C, Tullius S, Murphy G, Pomahac B, Kauke-Navarro M. Cellular activation pathways and interaction networks in vascularized composite allotransplantation. Frontiers In Immunology 2023, 14: 1179355. PMID: 37266446, PMCID: PMC10230044, DOI: 10.3389/fimmu.2023.1179355.Peer-Reviewed Original ResearchConceptsVascularized Composite AllotransplantationComposite allotransplantationRecipient-derived lymphocytesTreatment of patientsCellular activation pathwaysMultidrug immunosuppressionVCA graftsVCA patientsVCA rejectionGraft rejectionDevastating injuriesClinical managementNovel therapiesReconstructive surgeryLimb lossRejection responseFacial disfigurementAllotransplantationPatientsGraftActivation pathwayTissue cellsDifferent cell typesTissue typesCell typesPostoperative free flap monitoring in reconstructive surgery—man or machine?
Knoedler S, Hoch C, Huelsboemer L, Knoedler L, Stögner V, Pomahac B, Kauke-Navarro M, Colen D. Postoperative free flap monitoring in reconstructive surgery—man or machine? Frontiers In Surgery 2023, 10: 1130566. PMID: 36911625, PMCID: PMC9992807, DOI: 10.3389/fsurg.2023.1130566.Peer-Reviewed Original ResearchFree flap monitoringElderly patientsClinical examinationFlap monitoringAge-related morphologic changesFlap survival rateFree flap reconstructionFree tissue transferComplex tissue defectsPerioperative algorithmOlder patientsCancer resectionFlap appearancePrompt interventionClinical signsFlap reconstructionFree flapFlap compromiseSurvival rateMicrovascular anastomosisTissue transferTissue defectsMorphologic changesPostoperative free flap monitoringPatientsFacial Expression after Face Transplant: An International Face Transplant Cohort Comparison
Dorante M, Wang A, Kollar B, Perry B, Ertosun M, Lindford A, Kiukas E, Özkan Ö, Özkan Ö, Lassus P, Pomahac B. Facial Expression after Face Transplant: An International Face Transplant Cohort Comparison. Plastic & Reconstructive Surgery 2023, 152: 315e-325e. PMID: 36727808, DOI: 10.1097/prs.0000000000010242.Peer-Reviewed Original ResearchConceptsFT patientsHealthy controlsMotor function restorationMotor functionFace transplantFunction restorationAge-matched healthy controlsCLINICAL QUESTION/LEVELInterpositional nerve graftFull face transplantRespective healthy controlsMotor outcomeNerve coaptationFemale patientsNerve graftsPatientsPercentage restorationCohort comparisonFacial proceduresBilateral testsTransplantScore valuesFacial movements
2022
In the face of change: Which coping strategies predict better psychosocial outcomes in face transplant recipients?
Nizzi M, Pomahac B. In the face of change: Which coping strategies predict better psychosocial outcomes in face transplant recipients? Frontiers In Psychology 2022, 13: 995222. PMID: 36467137, PMCID: PMC9712221, DOI: 10.3389/fpsyg.2022.995222.Peer-Reviewed Original ResearchBetter mental healthPsychosocial outcomesMental healthLong-term psychosocial outcomesPre-transplant assessmentPost-transplant phasePost-transplant dataTerm psychosocial outcomesQuality of lifePoor mental healthMental health trajectoriesBetter psychosocial outcomesFace transplant recipientsTransplant recipientsTransplant candidatesMeasures of depressionPatients' qualityCoping strategiesPatientsPsychosocial functioningHealth trajectoriesMonthsOptimal outcomesPromising targetOutcomesmTORC1 Inhibition Protects Human Regulatory T Cells From Granzyme-B-Induced Apoptosis
Eskandari SK, Allos H, Al Dulaijan B, Melhem G, Sulkaj I, Alhaddad JB, Saad AJ, Deban C, Chu P, Choi JY, Kollar B, Pomahac B, Riella LV, Berger SP, Sanders JSF, Lieberman J, Li L, Azzi JR. mTORC1 Inhibition Protects Human Regulatory T Cells From Granzyme-B-Induced Apoptosis. Frontiers In Immunology 2022, 13: 899975. PMID: 35757726, PMCID: PMC9229986, DOI: 10.3389/fimmu.2022.899975.Peer-Reviewed Original ResearchConceptsRegulatory T cellsT cellsHuman regulatory T cellsHost THumanized mouse modelPro-apoptotic pathwaysSkin allotransplantationClinical efficacyImmunosuppressive potencyIntracytoplasmic expressionTransplant fieldMouse modelCellular therapyHigh expressionTarget cellsRapamycin complex 1Lysosomal granulesFunctional effectsMechanistic targetPatientsApoptosisC-JunGranzymesDrug targetsS6KCytomegalovirus-related Complications and Management in Facial Vascularized Composite Allotransplantation: An International Multicenter Retrospective Cohort Study
Kauke-Navarro M, Panayi AC, Formica R, Marty F, Parikh N, Foroutanjazi S, Safi AF, Mardini S, Razonable RR, Morelon E, Gelb B, Rodriguez E, Lassus P, Pomahac B. Cytomegalovirus-related Complications and Management in Facial Vascularized Composite Allotransplantation: An International Multicenter Retrospective Cohort Study. Transplantation 2022, 106: 2031-2043. PMID: 35389381, DOI: 10.1097/tp.0000000000004132.Peer-Reviewed Original ResearchConceptsRetrospective cohort studyAntiviral prophylaxisCohort studyComposite allotransplantationInternational multicenter retrospective cohort studyMulticenter retrospective cohort studyCMV-related complicationsFirst year posttransplantHigh-risk transplantsMore rejection episodesHigh-risk groupFacial Vascularized Composite AllotransplantationAllograft-related complicationsVascularized Composite AllotransplantationPaucity of dataAllograft lossCMV diseaseCMV viremiaCytomegalovirus serostatusR serostatusRejection episodesCMV infectionPrompt treatmentActive surveillancePatientsLongitudinal Recovery of Speech Motor Function Following Facial Transplantation: A Prospective Observational Study
Perry B, Eshghi M, Stipancic K, Richburg B, Ventresca H, Pomahac B, Green J. Longitudinal Recovery of Speech Motor Function Following Facial Transplantation: A Prospective Observational Study. The Laryngoscope 2022, 132: 2359-2367. PMID: 35218215, PMCID: PMC9402794, DOI: 10.1002/lary.30068.Peer-Reviewed Original ResearchConceptsFunctional speechSpeech intelligibilitySpeech recoveryLip strengthSpeech motor functionSpeech outcomesSentence intelligibility testMotor speech functionKinematic measuresProspective observational studyFacial transplantationRange of movementIntelligibility testIntelligibility improvementJaw rangeLongitudinal recoveryMotor functionObservational studyClinical measuresEarly recoveryJaw functionExtent of recoverySpeech functionSpeech improvementPatients
2021
The Modified 5-item Frailty Index Is a Risk Predictor in Breast Reconstruction: An Analysis of 40,415 Patients
Panayi A, Foroutanjazi S, Parikh B, Haug V, Kauke-Navarro M, Diehm Y, Pomahac B. The Modified 5-item Frailty Index Is a Risk Predictor in Breast Reconstruction: An Analysis of 40,415 Patients. Journal Of The American College Of Surgeons 2021, 233: s30. DOI: 10.1016/j.jamcollsurg.2021.07.037.Peer-Reviewed Original Research
2019
Blood proteome profiling using aptamer-based technology for rejection biomarker discovery in transplantation
Shubin A, Kollar B, Dillon S, Pomahac B, Libermann T, Riella L. Blood proteome profiling using aptamer-based technology for rejection biomarker discovery in transplantation. Scientific Data 2019, 6: 314. PMID: 31819064, PMCID: PMC6901551, DOI: 10.1038/s41597-019-0324-y.Peer-Reviewed Original ResearchConceptsDevastating facial injuriesSevere rejection episodesAcute transplant rejectionType of transplantationPeripheral blood serumSOMAscan proteomics platformSatisfactory treatment optionAcute rejectionRejection episodesTransplant statusTransplantation centersTransplant rejectionTreatment optionsBiomarker discoverySkin biopsiesClinical dataHigh riskFacial injuriesInvasive biomarkersTransplantationAptamer-based technologiesFace transplantationPatientsBlood serumSerum proteinsFive-Year Follow-up after Face Transplantation
Tasigiorgos S, Kollar B, Turk M, Perry B, Alhefzi M, Kiwanuka H, Nizzi M, Marty F, Chandraker A, Tullius S, Riella L, Pomahac B. Five-Year Follow-up after Face Transplantation. New England Journal Of Medicine 2019, 380: 2579-2581. PMID: 31141626, DOI: 10.1056/nejmc1810468.Peer-Reviewed Original ResearchFace transplantation
Sinha I, Vyas R, Pomahac B. Face transplantation. 2019, 379-382. DOI: 10.1093/med/9780199699537.003.0045.Peer-Reviewed Original ResearchReturn of sensationSevere traumatic injuryComposite tissue allotransplantationComposite tissue transplantationFacial composite tissue allotransplantationTransplanted allograftPost transplantationLifelong immunosuppressionMotor functionTraumatic injuryTissue allotransplantationPsychiatric issuesPatientsTissue transplantationInfection riskTransplantationFace transplantationFacial formImmunosuppressionAllograftsAllotransplantationInjuryPossible rejectionMonths
2018
Pediatric face transplantation
Dorante M, Tasigiorgos S, Pomahac B. Pediatric face transplantation. Current Opinion In Organ Transplantation 2018, 23: 598-604. PMID: 30080696, DOI: 10.1097/mot.0000000000000572.Peer-Reviewed Original ResearchConceptsFace transplantationPediatric hand transplantationImmunosuppression burdenRejection episodesDonor allograftsPatient demographicsPediatric patientsAppropriate patientsHand transplantationHand transplantTransplantationPediatric colleaguesPatientsYoung populationFace transplantSurgical innovationTransplantOutcomes