The Collagenase of the Bacterium Clostridium histolyticum in the Treatment of Irradiation-Induced Capsular Contracture
Diehm Y, Hirche C, Berger M, Heil J, Golatta M, Kotsougiani D, Pomahac B, Kneser U, Fischer S. The Collagenase of the Bacterium Clostridium histolyticum in the Treatment of Irradiation-Induced Capsular Contracture. Aesthetic Plastic Surgery 2018, 43: 836-844. PMID: 30456640, DOI: 10.1007/s00266-018-1267-y.Peer-Reviewed Original ResearchConceptsBacterium Clostridium histolyticumCapsular fibrosisHematoma formationTreatment optionsImplant pocketClostridium histolyticumSilicone implantsMiniature silicone implantsNovel treatment optionsPotential treatment optionInjection of collagenaseVessel wall architectureMethodsThirty-six ratsVessel wall thicknessCollagenase injectionSignificant complicationsBreast reconstructionCapsular contractureClinical safetyBreast cancerDay 1Application of collagenaseDay 120Implant sitesThin capsule