2022
mTORC1 Inhibition Protects Human Regulatory T Cells From Granzyme-B-Induced Apoptosis
Eskandari SK, Allos H, Al Dulaijan B, Melhem G, Sulkaj I, Alhaddad JB, Saad AJ, Deban C, Chu P, Choi JY, Kollar B, Pomahac B, Riella LV, Berger SP, Sanders JSF, Lieberman J, Li L, Azzi JR. mTORC1 Inhibition Protects Human Regulatory T Cells From Granzyme-B-Induced Apoptosis. Frontiers In Immunology 2022, 13: 899975. PMID: 35757726, PMCID: PMC9229986, DOI: 10.3389/fimmu.2022.899975.Peer-Reviewed Original ResearchConceptsRegulatory T cellsT cellsHuman regulatory T cellsHost THumanized mouse modelPro-apoptotic pathwaysSkin allotransplantationClinical efficacyImmunosuppressive potencyIntracytoplasmic expressionTransplant fieldMouse modelCellular therapyHigh expressionTarget cellsRapamycin complex 1Lysosomal granulesFunctional effectsMechanistic targetPatientsApoptosisC-JunGranzymesDrug targetsS6K
2012
Craniofacial Principles in Face Transplantation
Caterson E, Diaz-Siso J, Shetye P, Junker J, Bueno E, Soga S, Rybicki F, Pomahac B. Craniofacial Principles in Face Transplantation. Journal Of Craniofacial Surgery 2012, 23: 1234-1238. PMID: 22948648, DOI: 10.1097/scs.0b013e318252d406.Peer-Reviewed Original ResearchConceptsSkull baseFace transplantationFace transplantFace transplant recipientsSella-nasion planeSoft tissue elementsTransplant recipientsAirway functionDonor allograftsAnatomical restorationUpper airwayCraniofacial principlesPostoperative analysisNormal anatomyTransplantationFrankfort horizontal planeSoft tissueHard tissue componentsFunctional effectsCephalometric parametersOrthognathic planningTissue elementsTransplantNormative dataTissue components