Efficacy and Safety of the Collagenase of the Bacterium Clostridium Histolyticum for the Treatment of Capsular Contracture after Silicone Implants: Ex-Vivo Study on Human Tissue
Fischer S, Hirche C, Diehm Y, Nuutila K, Kiefer J, Gazyakan E, Bueno E, Kremer T, Kneser U, Pomahac B. Efficacy and Safety of the Collagenase of the Bacterium Clostridium Histolyticum for the Treatment of Capsular Contracture after Silicone Implants: Ex-Vivo Study on Human Tissue. PLOS ONE 2016, 11: e0156428. PMID: 27232716, PMCID: PMC4883774, DOI: 10.1371/journal.pone.0156428.Peer-Reviewed Original ResearchConceptsFull-thickness skin graftThickness skin graftBacterium Clostridium histolyticumCapsular contractureSkin graftsBreast sitesSilicone implantsReasonable treatment optionClostridium histolyticumFibrotic capsuleCollagen subtypesEx vivo studyCollagenase doseEx-vivo settingTreatment optionsContracture tissueAcellular tissue matrixOutcome measuresHistological assessmentSubtype 4Capsule tissueClinical utilizationDifferent dosesClinical realityType 4