2023
Insights from immunoproteomic profiling of a rejected full-face transplant
Lee C, Wang D, Kauke-Navarro M, Russell-Goldman E, Xu S, Mucciarone K, Sohrabi S, Lian C, Pomahac B, Murphy G. Insights from immunoproteomic profiling of a rejected full-face transplant. American Journal Of Transplantation 2023, 23: 1058-1061. PMID: 37037378, DOI: 10.1016/j.ajt.2023.04.008.Peer-Reviewed Original ResearchConceptsVascularized Composite AllograftsT cellsChronic rejectionCD8-positive T cellsEffector T cellsFull face transplantArteriosclerotic alterationsIntragraft arteriesVCA rejectionGraft arteryAccelerated arteriosclerosisRecipient originPunch biopsyAtherogenic responseComposite allograftsImmunoproteomic profilingDioxygenase 1Target endotheliumArteryEndotheliumProteomic profilingPathway componentsCellsRejectionAllografts
2021
CD1a selectively captures endogenous cellular lipids that broadly block T cell response
Cotton R, Wegrecki M, Cheng T, Chen Y, Veerapen N, Le Nours J, Orgill D, Pomahac B, Talbot S, Willis R, Altman J, de Jong A, Van Rhijn I, Clark R, Besra G, Ogg G, Rossjohn J, Moody D. CD1a selectively captures endogenous cellular lipids that broadly block T cell response. Journal Of Experimental Medicine 2021, 218: e20202699. PMID: 33961028, PMCID: PMC8111460, DOI: 10.1084/jem.20202699.Peer-Reviewed Original ResearchConceptsNatural endogenous inhibitorsEndogenous lipidsCD1a proteinCellular lipidsT cell activationMembrane phospholipidsLonger lipidsSurface residuesEndogenous inhibitorLipidomics methodDetailed chemical structureCell activationLipidsCellsNatural blockerSphingolipidsDisplay platformProteinCrystal structureResiduesCell responsesBindingTetramerC42SphingomyelinHuman skin is colonized by T cells that recognize CD1a independently of lipid
Cotton R, Cheng T, Wegrecki M, Le Nours J, Orgill D, Pomahac B, Talbot S, Willis R, Altman J, de Jong A, Ogg G, Van Rhijn I, Rossjohn J, Clark R, Moody D. Human skin is colonized by T cells that recognize CD1a independently of lipid. Journal Of Clinical Investigation 2021, 131: e140706. PMID: 33393500, PMCID: PMC7773353, DOI: 10.1172/jci140706.Peer-Reviewed Original ResearchConceptsT cellsSelf-lipid antigensSkin T cellsT cell autoreactivityT cell poolT cell repertoireMajor antigenic targetAntigenic targetsCell repertoireClinical diseaseCD1aSkin diseasesCD1 proteinsAntigenTCR recognitionCell poolEffector moleculesCD1a proteinLipid ligandsSmall antigensDiseaseHuman skinCellsAutoreactivityLipids