Dermatan sulfate activates nuclear factor-κb and induces endothelial and circulating intercellular adhesion molecule-1
Penc S, Pomahac B, Eriksson E, Detmar M, Gallo R. Dermatan sulfate activates nuclear factor-κb and induces endothelial and circulating intercellular adhesion molecule-1. Journal Of Clinical Investigation 1999, 103: 1329-1335. PMID: 10225976, PMCID: PMC408352, DOI: 10.1172/jci4742.Peer-Reviewed Original ResearchConceptsICAM-1Effect of DSDermatan sulfateCell surface ICAM-1Intercellular adhesion molecule-1Endothelial cellsCultured human dermal microvascular endothelial cellsIntercellular adhesion molecule-1 mRNAIL-1 releaseAdhesion molecule-1Surface ICAM-1Human dermal microvascular endothelial cellsDermal microvascular endothelial cellsMicrovascular endothelial cellsNF-kappaB activationNuclear factor-kappaBTNF-alphaInflammatory phaseMolecule-1Chondroitin sulfate BFactor-kappaBSoluble ICAMChondroitin sulfate ANF-kappaBPhysiologic concentrations