2021
Epigenetic states in the human placenta: A singular epigenome for an exceptional tissue
Lesch BJ. Epigenetic states in the human placenta: A singular epigenome for an exceptional tissue. Developmental Cell 2021, 56: 1211-1212. PMID: 33945779, DOI: 10.1016/j.devcel.2021.04.011.Commentaries, Editorials and LettersConceptsPlacental cells
2016
Parallel evolution of male germline epigenetic poising and somatic development in animals
Lesch BJ, Silber SJ, McCarrey JR, Page DC. Parallel evolution of male germline epigenetic poising and somatic development in animals. Nature Genetics 2016, 48: 888-894. PMID: 27294618, DOI: 10.1038/ng.3591.Peer-Reviewed Original Research
2014
Poised chromatin in the mammalian germ line
Lesch BJ, Page DC. Poised chromatin in the mammalian germ line. Development 2014, 141: 3619-3626. PMID: 25249456, PMCID: PMC4197577, DOI: 10.1242/dev.113027.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMammalian germ lineGerm cell identityCell identityGerm lineMammalian germ cellsEmbryonic stem cellsChromatin stateEpigenetic inheritanceHistone modificationsRegulatory genesGene activationDNA methylationEpigenetic featuresChromatinGerm cellsStem cellsSomatic developmentGenesPromoterFetal stageTotipotencyCellsMeiosisGametogenesisRepressionA Chromatin-Dependent Role of the Fragile X Mental Retardation Protein FMRP in the DNA Damage Response
Alpatov R, Lesch BJ, Nakamoto-Kinoshita M, Blanco A, Chen S, Stützer A, Armache KJ, Simon MD, Xu C, Ali M, Murn J, Prisic S, Kutateladze TG, Vakoc CR, Min J, Kingston RE, Fischle W, Warren ST, Page DC, Shi Y. A Chromatin-Dependent Role of the Fragile X Mental Retardation Protein FMRP in the DNA Damage Response. Cell 2014, 157: 869-881. PMID: 24813610, PMCID: PMC4038154, DOI: 10.1016/j.cell.2014.03.040.Peer-Reviewed Original ResearchConceptsDNA damage responseMental retardation protein FMRPProtein FMRPFragile X syndromeDDR machineryDamage responseChromatin-binding proteinsTandem Tudor domainTranslation of proteinsX syndromeChromatin interfaceFMRP bindsTudor domainMeiotic chromosomesGenomic stabilityFMRPDevelopmental processesMouse spermatogenesisGametogenesisDependent mannerSynaptic functionMachineryProteinChromatinImportant role