2019
A universal transportin protein drives stochastic choice of olfactory neurons via specific nuclear import of a sox-2-activating factor
Alqadah A, Hsieh YW, Xiong R, Lesch BJ, Chang C, Chuang CF. A universal transportin protein drives stochastic choice of olfactory neurons via specific nuclear import of a sox-2-activating factor. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 25137-25146. PMID: 31767767, PMCID: PMC6911211, DOI: 10.1073/pnas.1908168116.Peer-Reviewed Original ResearchConceptsBK potassium channelsNuclear importUnbiased forward genetic screenSpecific nuclear importForward genetic screenCell fate choiceTranscription factor SOX-2Notch-independent mechanismStructure-function insightsPotassium channelsHigh mobility groupProtein kinase pathwayAmino acid residuesAWC asymmetryGenetic screenFunction mutantsHuman neurological disordersAWC neuronsFate choiceKinase pathwayBiological processesAcid residuesMobility groupCalcium signalingSox-2
2012
Genetics of germ cell development
Lesch BJ, Page DC. Genetics of germ cell development. Nature Reviews Genetics 2012, 13: 781-794. PMID: 23044825, DOI: 10.1038/nrg3294.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnimalsCaenorhabditis elegansDrosophila melanogasterFemaleGene Expression Regulation, DevelopmentalMaleMiceModels, GeneticOocytesSignal TransductionSpermatocytesConceptsGerm cell developmentGerm cellsHaploid genomeMultiple speciesCell developmentPluripotent stem cell systemsRepressive chromatin configurationGerm cell identityRNA polymerase IIGerm cell biologyStem cell systemEarly germ cellsPolymerase IICell identityDiploid genomeChromatin configurationIndividual organismsCell biologyMitotic proliferationGenomeSame speciesDifferent speciesGermline precursorsLater stepsMeiosis