2023
KDM6A/UTX promotes spermatogenic gene expression across generations and is not required for male fertility†
Walters B, Rainsford S, Heuer R, Dias N, Huang X, de Rooij D, Lesch B. KDM6A/UTX promotes spermatogenic gene expression across generations and is not required for male fertility†. Biology Of Reproduction 2023, 110: 391-407. PMID: 37861693, PMCID: PMC11484508, DOI: 10.1093/biolre/ioad141.Peer-Reviewed Original ResearchMale germ lineGerm lineGenome-wide epigenetic profilingGene regulatory statesHeritable epigenetic statesHundreds of genesLoss of KDM6AEarly meiotic prophaseSpermatogenic cellsSpermatogenic gene expressionKDM6A/UTXPaternal germ lineDemethylation of H3K27me3H3K27me3 peaksH3K27me3 domainsMisregulated genesEpigenetic stateChromatin organizationRepressive modificationsTranscriptional activatorMammalian spermatogenesisChromatin undergoesLysine demethylase 6AEpigenetic profilingGene activation
2019
Intergenerational epigenetic inheritance of cancer susceptibility in mammals
Lesch BJ, Tothova Z, Morgan EA, Liao Z, Bronson RT, Ebert BL, Page DC. Intergenerational epigenetic inheritance of cancer susceptibility in mammals. ELife 2019, 8: e39380. PMID: 30963999, PMCID: PMC6456297, DOI: 10.7554/elife.39380.Peer-Reviewed Original ResearchConceptsGerm lineEpigenetic changesParental germ lineIntergenerational epigenetic inheritanceRegulation of genesPaternal germ lineCancer susceptibilityChromatin regulatorsEpigenetic inheritanceH3K27me3 marksHypermethylated regionsDNA methylationSomatic tissuesMale gametesElevated tumor incidenceCancer initiationGenetic variantsGermline deletionMutantsHeritabilityDeletionSuccessive generationsSpermOffspringWild-type mice