A universal transportin protein drives stochastic choice of olfactory neurons via specific nuclear import of a sox-2-activating factor
Alqadah A, Hsieh YW, Xiong R, Lesch BJ, Chang C, Chuang CF. A universal transportin protein drives stochastic choice of olfactory neurons via specific nuclear import of a sox-2-activating factor. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 25137-25146. PMID: 31767767, PMCID: PMC6911211, DOI: 10.1073/pnas.1908168116.Peer-Reviewed Original ResearchConceptsBK potassium channelsNuclear importUnbiased forward genetic screenSpecific nuclear importForward genetic screenCell fate choiceTranscription factor SOX-2Notch-independent mechanismStructure-function insightsPotassium channelsHigh mobility groupProtein kinase pathwayAmino acid residuesAWC asymmetryGenetic screenFunction mutantsHuman neurological disordersAWC neuronsFate choiceKinase pathwayBiological processesAcid residuesMobility groupCalcium signalingSox-2