2023
Duration of antimicrobial treatment for complicated intra-abdominal infections after definitive source control: A systematic review, meta-analysis, and practice management guideline from the Eastern Association for the Surgery of Trauma
H. J, Rattan R, Patel N, Bhattacharya B, Butts C, Gupta S, Asfaw S, Como J, Sahr S, Bugaev N. Duration of antimicrobial treatment for complicated intra-abdominal infections after definitive source control: A systematic review, meta-analysis, and practice management guideline from the Eastern Association for the Surgery of Trauma. Journal Of Trauma And Acute Care Surgery 2023, 95: 603-612. PMID: 37316989, DOI: 10.1097/ta.0000000000003998.Peer-Reviewed Original ResearchConceptsComplicated intra-abdominal infectionsDefinitive source controlIntra-abdominal infectionsSurgery of TraumaAntimicrobial treatmentSystematic reviewAdult patientsLonger durationEastern AssociationDuration of antibioticsShorter antibiotic coursesPractice management guidelinesSurgical site infectionLevel of evidenceTerms of mortalitySource controlAntibiotic coursesRecurrent abscessesAntibiotic regimensHospital lengthRecommendations AssessmentSite infectionAntimicrobial durationLevel IIIMeta-AnalysisRoutine post-operative labs and healthcare system burden in acute appendicitis
Sznol J, Becher R, Maung A, Bhattacharya B, Davis K, Schuster K. Routine post-operative labs and healthcare system burden in acute appendicitis. The American Journal Of Surgery 2023, 226: 571-577. PMID: 37291012, DOI: 10.1016/j.amjsurg.2023.06.005.Peer-Reviewed Original ResearchConceptsHealthcare system burdenSystem burdenHealth care costsAppendicitis managementIncreased LOSUncomplicated AAAcute appendicitisRetrospective cohortClinical courseClinical variablesPatient populationMinimal comorbiditiesMultivariable modelingHealthcare costsCare costsPatientsLaboratory utilizationNational Health Expenditure AccountsLab utilizationLaboratory testingBurdenLaboratory testsAppendicitisComorbiditiesCohort
2022
Academic Medical Centers Experienced Higher Rates of Post-Operative Health-Care–Associated Infections during the COVID-19 Pandemic: A Post Hoc Analysis of an Eastern Association for the Surgery of Trauma Multicenter Trial
Tracy BM, Valdez CL, Crowley B, Seng S, Ratnasekera A, Collins CM, Bhattacharya B, O'Connor R, Sharp V, Gelbard RB. Academic Medical Centers Experienced Higher Rates of Post-Operative Health-Care–Associated Infections during the COVID-19 Pandemic: A Post Hoc Analysis of an Eastern Association for the Surgery of Trauma Multicenter Trial. Surgical Infections 2022, 23: 538-544. PMID: 35917388, DOI: 10.1089/sur.2022.148.Peer-Reviewed Original ResearchConceptsAcademic medical centerRisk factorsMedical CenterConcomitant COVID-19 infectionPost-operative healthTrauma multicenter trialIndependent risk factorSurgical site infectionInfection prevention effortsImportance of adherenceMulti-center studyCOVID-19 infectionCoronavirus disease 2019COVID-19 pandemicPost Hoc AnalysisHigh rateAppendicitis severityAcute appendicitisMulticenter trialPrimary outcomeSite infectionCommon HAIHoc AnalysisHospital typeDisease 2019
2021
Concerns Regarding Surgeon Special Interest and Years Following Termination of Training—Reply
Schuster KM, Bhattacharya B. Concerns Regarding Surgeon Special Interest and Years Following Termination of Training—Reply. JAMA Surgery 2021, 156: 1182-1183. PMID: 34347023, DOI: 10.1001/jamasurg.2021.3621.Peer-Reviewed Original ResearchHumansSurgeonsIncreased mortality with resuscitative endovascular balloon occlusion of the aorta only mitigated by strong unmeasured confounding: An expanded analysis using the National Trauma Data Bank
Linderman GC, Lin W, Becher RD, Maung AA, Bhattacharya B, Davis KA, Schuster KM. Increased mortality with resuscitative endovascular balloon occlusion of the aorta only mitigated by strong unmeasured confounding: An expanded analysis using the National Trauma Data Bank. Journal Of Trauma And Acute Care Surgery 2021, 91: 790-797. PMID: 33951027, PMCID: PMC8547242, DOI: 10.1097/ta.0000000000003265.Peer-Reviewed Original ResearchConceptsAcute kidney injuryResuscitative endovascular balloon occlusionLower extremity amputationEndovascular balloon occlusionBalloon occlusionExtremity amputationTraumatic injuryTreatment weightingREBOA placementNational Trauma Data BankInverse probabilityPlacement of REBOATrauma Data BankSevere traumatic injuryMortality effectsUnmeasured confoundersNoncompressible torso hemorrhagePotent confounderTQIP dataTQIP databaseAortic injuryKidney injuryRetrospective studyInjury patternsBaseline variablesImproved outcomes using laparoscopy for emergency colectomy after mitigating bias by negative control exposure analysis
Linderman GC, Lin W, Sanghvi MR, Becher RD, Maung AA, Bhattacharya B, Davis KA, Schuster KM. Improved outcomes using laparoscopy for emergency colectomy after mitigating bias by negative control exposure analysis. Surgery 2021, 171: 305-311. PMID: 34332782, DOI: 10.1016/j.surg.2021.06.048.Peer-Reviewed Original ResearchConceptsOpen surgeryEmergency colectomyNational Surgical Quality Improvement Program dataQuality Improvement Program dataPostoperative septic shockLow-risk patientsSurgical site infectionPatients meeting criteriaColorectal emergenciesElective colectomyUnderwent laparoscopyHospital stayOverall morbidityNationwide registryAnastomotic leakColectomy casesConverted groupSeptic shockSite infectionPatient selectionBaseline variablesImproved outcomesLaparoscopic surgeryTreatment weightingColectomyAnticoagulation Is Associated with Increased Mortality in Splenic Injuries
Bhattacharya B, Becher RD, Schuster KM, Davis KA, Maung AA. Anticoagulation Is Associated with Increased Mortality in Splenic Injuries. Journal Of Surgical Research 2021, 266: 1-5. PMID: 33975026, DOI: 10.1016/j.jss.2021.04.002.Peer-Reviewed Original ResearchConceptsNon-ACS patientsSplenic injuryAC patientsMultivariable binary logistic regressionIndependent risk factorEffect of anticoagulationInjury Severity ScoreUnits of RBCsBinary logistic regressionHospital courseMedian LOSIncreased MortalitySeverity scoreRisk factorsWorse outcomesAnticoagulationSplenic surgeryAC groupPatientsHigh mortalityInjuryLogistic regressionMortalitySerious injuriesAngiographyAssociation of Acute Care Surgeon Experience With Emergency Surgery Patient Outcomes and Mortality
Schuster KM, Hazelton JP, Rattigan D, Perez JM, Bhattacharya B. Association of Acute Care Surgeon Experience With Emergency Surgery Patient Outcomes and Mortality. JAMA Surgery 2021, 156: 472-478. PMID: 33688932, PMCID: PMC7948108, DOI: 10.1001/jamasurg.2021.0041.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdultAgedBlood TransfusionClinical CompetenceEmergenciesFemaleHumansLength of StayMaleMiddle AgedPostoperative HemorrhagePostoperative PeriodReoperationRisk FactorsShock, SepticSurgeonsSurgical Wound InfectionSurvival RateTime FactorsTrauma CentersTreatment OutcomeUnited StatesWounds and InjuriesYoung AdultConceptsEmergency surgery outcomesEmergency Surgery ScoreMore septic shockEmergency surgical proceduresLength of staySurgeon experienceUnplanned returnOlder patientsSeptic shockSurgery scoreKidney failureSurgery outcomesOperating roomSurgical proceduresSurgeon groupAcademic level 1 trauma centerOrgan space surgical site infectionEmergency general surgical careLevel 1 trauma centerYears of experienceGeneral surgical interventionEmergency general surgeryAcute care surgeonsAcute kidney failureSurgical site infection
2020
The effect of anticoagulation on outcomes after liver and spleen injuries: A research consortium of New England centers for trauma (ReCONECT) study
Bhattacharya B, Askari R, Davis KA, Dorfman J, Eid AI, Elsharkawy AE, Kasotakis G, Mackey S, Odom S, Okafor BU, Rosenblatt M, Ruditsky A, Velmahos G, Maung AA. The effect of anticoagulation on outcomes after liver and spleen injuries: A research consortium of New England centers for trauma (ReCONECT) study. Injury 2020, 51: 1994-1998. PMID: 32482426, DOI: 10.1016/j.injury.2020.05.002.Peer-Reviewed Original ResearchConceptsNon-ACS patientsEffect of anticoagulationNon-operative managementSpleen injurySplenic injuryLiver injuryInitial non-operative managementSignificant differencesUse of anticoagulationBlood product transfusionMulticenter retrospective studyAC drugsMore PRBCsInjury gradeProduct transfusionCommon indicationAC patientsAtrial fibrillationRetrospective studyAnticoagulationSolid organsPatientsInjuryStudy periodLiver
2019
Antimotility agents for the treatment of acute noninfectious diarrhea in critically ill patients: A practice management guideline from the Eastern Association for the Surgery of Trauma.
Bugaev N, Bhattacharya B, Chiu WC, Como JJ, Cripps MW, Ferrada P, Gelbard RB, Gondek S, Kasotakis G, Kim D, Mentzer C, Robinson BRH, Salcedo ES, Yeh DD. Antimotility agents for the treatment of acute noninfectious diarrhea in critically ill patients: A practice management guideline from the Eastern Association for the Surgery of Trauma. Journal Of Trauma And Acute Care Surgery 2019, 87: 915-921. PMID: 31574060, DOI: 10.1097/ta.0000000000002449.Peer-Reviewed Original ResearchConceptsDiphenoxylate/atropineNoninfectious diarrheaSurgery of TraumaElemental dietIll adultsIll patientsEastern AssociationIntensive care unit patientsResolution of diarrheaPractice management guidelinesCare unit patientsDaily clinical practiceLevel of evidenceDiarrhea resolutionFecal frequencyAntimotility agentsHospital lengthRecommendations AssessmentUnit patientsClinical diarrheaDiarrheaClinical practiceAtropineLevel IIIPatientsPromotility agents for the treatment of ileus in adult surgical patients: A practice management guideline from the Eastern Association for the Surgery of Trauma.
Bugaev N, Bhattacharya B, Chiu WC, Como JJ, Cripps MW, Ferrada P, Gelbard RB, Gondek S, Kasotakis G, Kim D, Mentzer C, Robinson BRH, Salcedo ES, Yeh DD. Promotility agents for the treatment of ileus in adult surgical patients: A practice management guideline from the Eastern Association for the Surgery of Trauma. Journal Of Trauma And Acute Care Surgery 2019, 87: 922-934. PMID: 31136527, DOI: 10.1097/ta.0000000000002381.Peer-Reviewed Original ResearchConceptsEarly enteral nutritionAdult surgical patientsResolution of ileusNormal bowel functionSurgery of TraumaSurgical patientsBowel functionHospital lengthEastern AssociationEffectiveness of metoclopramideEnteral feeding goalsEnteral nutrition goalsPractice management guidelinesEffect of metoclopramideTreatment of ileusMultiple medical interventionsDaily clinical practiceLevel of evidenceNeurohormonal dysfunctionEnteral nutritionPromotility agentsRecommendations AssessmentExogenous opioidsFluid overloadSupportive careContemporary management of spontaneous retroperitoneal and rectus sheath hematomas
Warren MH, Bhattacharya B, Maung AA, Davis KA. Contemporary management of spontaneous retroperitoneal and rectus sheath hematomas. The American Journal Of Surgery 2019, 219: 707-710. PMID: 31109633, DOI: 10.1016/j.amjsurg.2019.05.002.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngiographyAnticoagulantsBlood Component TransfusionEmbolization, TherapeuticFemaleHematomaHumansInternational Normalized RatioLength of StayMaleMiddle AgedPlatelet Aggregation InhibitorsProthrombin TimeRectal DiseasesRetroperitoneal SpaceRetrospective StudiesShock, HemorrhagicTomography, X-Ray ComputedConceptsSheath hematomaSurgical interventionBlood product transfusionOptimal treatment strategySpontaneous retroperitonealIntravenous heparinProduct transfusionAdult patientsMedian ageAntiplatelet agentsHemorrhagic shockDisease progressionBlood productsTreatment strategiesCT scanHematomaOutcome dataPatientsOne-year periodContemporary managementSpecific agentsAngioembolizationRetroperitonealInterventionAgentsEvaluation of Swallow Function Post-Extubation: Is It Necessary to Wait 24 Hours?
Leder SB, Warner HL, Suiter DM, Young NO, Bhattacharya B, Siner JM, Davis KA, Maerz LL, Rosenbaum SH, Marshall PS, Pisani MA, Siegel MD, Brennan JJ, Schuster KM. Evaluation of Swallow Function Post-Extubation: Is It Necessary to Wait 24 Hours? Annals Of Otology Rhinology & Laryngology 2019, 128: 619-624. PMID: 30841709, DOI: 10.1177/0003489419836115.Peer-Reviewed Original ResearchConceptsIntensive care unitSwallow evaluationDifferent intensive care unitsRe-intubation rateYale Swallow ProtocolMajority of patientsPost-extubation dysphagiaIntubation durationNosocomial pneumoniaPost extubationLonger hospitalizationCare unitProspective InvestigationSwallow ProtocolSwallowingHoursDysphagiaHospitalizationIntubationPneumoniaPatientsIncidenceEvaluation
2018
Can acute care surgeons perform while fatigued? An EAST multicenter study
Schuster KM, Hazelton JP, Rattigan D, Nguyen L, Kim D, Spence LH, Turay D, Luo-Owen X, Perez JM, Dayal S, Blatt M, Hill C, Bhattacharya B. Can acute care surgeons perform while fatigued? An EAST multicenter study. Journal Of Trauma And Acute Care Surgery 2018, 85: 476-484. PMID: 29787535, DOI: 10.1097/ta.0000000000001975.Peer-Reviewed Original ResearchConceptsAcute care surgeonsMajor morbidityPatient outcomesAcute care surgery serviceEAST multicenter studyPatient-level factorsEmergency casesFour-level ordinal scaleHours of sleepHierarchical logistic regression modelsImpact of fatigueLogistic regression modelsPatient factorsFemale patientsSurgery serviceMulticenter studyLevel IVImmediate operationPrognostic studiesSleep timePatient volumeSimilar outcomesMorbiditySurgeonsMortalityRelationship between duration of preoperative symptoms and postoperative ileus for small bowel obstruction
Brandt WS, Wood J, Bhattacharya B, Pei K, Davis KA, Schuster K. Relationship between duration of preoperative symptoms and postoperative ileus for small bowel obstruction. Journal Of Surgical Research 2018, 225: 40-44. PMID: 29605033, DOI: 10.1016/j.jss.2017.12.031.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAscitesEquipment and Supplies UtilizationFemaleFood IntoleranceHumansIleusIntensive Care UnitsIntestinal ObstructionIntestine, SmallLength of StayMaleMiddle AgedParenteral NutritionPostoperative ComplicationsPreoperative PeriodRetrospective StudiesRisk FactorsTime FactorsTime-to-TreatmentYoung AdultConceptsTolerance of dietSmall bowel obstructionPreoperative symptomsLength of stayPostoperative ileusUnivariable analysisTotal durationIntensive care unit admissionTotal parenteral nutrition useParenteral nutrition useCare unit admissionIntensive care unitPreoperative ascitesBowel obstructionPrimary endpointSecondary endpointsSymptom durationUnit admissionMedian durationOperative interventionPostoperative outcomesCare unitMultivariable analysisRetrospective reviewNutrition use
2017
Metabolic acidosis and the role of unmeasured anions in critical illness and injury
Zingg T, Bhattacharya B, Maerz LL. Metabolic acidosis and the role of unmeasured anions in critical illness and injury. Journal Of Surgical Research 2017, 224: 5-17. PMID: 29506851, DOI: 10.1016/j.jss.2017.11.013.Peer-Reviewed Original ResearchUncertainty Among Acute Care Surgery Providers Does Not Change with Experience.
Bhattacharya B, Maung A, Schuster K, Davis KA. Uncertainty Among Acute Care Surgery Providers Does Not Change with Experience. Connecticut Medicine 2017, 81: 133-139. PMID: 29772154.Peer-Reviewed Original Research
2016
Trauma patients on new oral anticoagulation agents have lower mortality than those on warfarin
Maung AA, Bhattacharya B, Schuster KM, Davis KA. Trauma patients on new oral anticoagulation agents have lower mortality than those on warfarin. Journal Of Trauma And Acute Care Surgery 2016, 81: 652-657. PMID: 27438683, DOI: 10.1097/ta.0000000000001189.Peer-Reviewed Original ResearchConceptsNew oral agentsNew oral anticoagulation agentsOral anticoagulation agentsAnticoagulation agentsControl groupLevel 1 trauma center databaseLower mortalityTrauma-related mortalityInjury Severity ScoreMechanism of injuryIntensive care unitMultivariable logistic regressionHigher overall mortalityTrauma center databaseTraumatic brain injuryElectronic medical recordsWarfarin groupHospital courseOral agentsControl patientsIndependent predictorsOverall mortalityTrauma patientsCare unitRetrospective reviewAnesthesia for Patients with Traumatic Brain Injuries
Bhattacharya B, Maung AA. Anesthesia for Patients with Traumatic Brain Injuries. Anesthesiology Clinics 2016, 34: 747-759. PMID: 27816132, DOI: 10.1016/j.anclin.2016.06.009.Peer-Reviewed Original ResearchPostoperative delirium is associated with increased intensive care unit and hospital length of stays after liver transplantation
Bhattacharya B, Maung A, Barre K, Maerz L, Rodriguez-Davalos MI, Schilsky M, Mulligan DC, Davis KA. Postoperative delirium is associated with increased intensive care unit and hospital length of stays after liver transplantation. Journal Of Surgical Research 2016, 207: 223-228. PMID: 27979481, DOI: 10.1016/j.jss.2016.08.084.Peer-Reviewed Original ResearchConceptsLiver transplantationHospital lengthEnd-stage liver disease (MELD) scoreIntensive care unit LOSHigher preoperative modelImportant postoperative complicationLiver Disease scoreLiver transplant patientsImpact of deliriumTertiary care centerRetrospective case seriesUrinary tract infectionFurther prospective studiesIntensive care unitLong-term outcomesSpecific risk factorsFrequency of hospitalPaucity of dataPostoperative deliriumPostoperative hospitalPostoperative complicationsTransplant patientsVentilator daysAdult patientsDelirious patients