2004
Phase II Trial of Bortezomib for Patients With Advanced Renal Cell Carcinoma
Kondagunta GV, Drucker B, Schwartz L, Bacik J, Marion S, Russo P, Mazumdar M, Motzer RJ. Phase II Trial of Bortezomib for Patients With Advanced Renal Cell Carcinoma. Journal Of Clinical Oncology 2004, 22: 3720-3725. PMID: 15365068, DOI: 10.1200/jco.2004.10.155.Peer-Reviewed Original ResearchConceptsMetastatic renal cell carcinomaRenal cell carcinomaGrade 3 sensory neuropathyPartial responseSensory neuropathyCell carcinomaM2 groupAdvanced renal cell carcinomaToxicity of bortezomibPhase II trialAssessable patientsStable diseaseII trialInterferon alfaUnacceptable toxicityClinical responseCytokine therapyCombination therapyIntravenous administrationNovel agentsIndividual patientsDose reductionResponse durationHigh doseAntitumor effects
2003
Prognostic Factors for Metastatic Kidney Cancer
Drucker BJ, Mazumdar M, Motzer RJ. Prognostic Factors for Metastatic Kidney Cancer. Cancer Treatment And Research 2003, 116: 139-153. PMID: 14650830, DOI: 10.1007/978-1-4615-0451-1_8.Peer-Reviewed Original ResearchConceptsResponse rateMetastatic renal cell carcinomaStudy of immunotherapyEffective systemic therapyMetastatic kidney cancerStandard cytotoxic chemotherapyRenal cell cancerSpontaneous tumor regressionRenal cell carcinomaSignificant antitumor effectHormonal therapyUntreated patientsCytotoxic chemotherapyHormone therapyMetastatic RCCSystemic therapyPrognostic factorsCell cancerLymphocytic infiltrationPoor prognosisCell carcinomaRenal tumorsTumor regressionKidney cancerAntitumor effects