Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
Pasquinelli A, Reinhart B, Slack F, Martindale M, Kuroda M, Maller B, Hayward D, Ball E, Degnan B, Müller P, Spring J, Srinivasan A, Fishman M, Finnerty J, Corbo J, Levine M, Leahy P, Davidson E, Ruvkun G. Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature 2000, 408: 86-89. PMID: 11081512, DOI: 10.1038/35040556.Peer-Reviewed Original ResearchConceptsLin-4Regulatory RNAsProtein-coding target genesLarval stagesAdult cell fateLin-4 RNASecond larval stageLate larval stagesAnimal phylogenyPoriferan speciesCaenorhabditis elegansRNA genesC. elegansSmall RNAsCell fateTemporal regulationTarget genesLate larvalLet-7Untranslated regionAdult stageTemporal expressionRNAEscherichia coliAnimal species