2008
The let-7 microRNA target gene, Mlin41/Trim71 is required for mouse embryonic survival and neural tube closure
Maller Schulman BR, Liang X, Stahlhut C, DelConte C, Stefani G, Slack FJ. The let-7 microRNA target gene, Mlin41/Trim71 is required for mouse embryonic survival and neural tube closure. Cell Cycle 2008, 7: 3935-3942. PMID: 19098426, PMCID: PMC2895810, DOI: 10.4161/cc.7.24.7397.Peer-Reviewed Original ResearchConceptsLin-41Neural tube closureTube closureTerminal differentiationPrecocious cell cycle exitNematode Caenorhabditis elegansMore complex organismsCell cycle exitKey developmental eventsMicroRNA target genesNeural tube closure defectsLet-7 microRNACaenorhabditis elegansEpidermal skin cellsEmbryonic lethalityCycle exitComplex organismsTarget genesLet-7Developmental eventsDisease genesMouse mutantsClosure defectsMutantsFunctional role
2000
Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
Pasquinelli A, Reinhart B, Slack F, Martindale M, Kuroda M, Maller B, Hayward D, Ball E, Degnan B, Müller P, Spring J, Srinivasan A, Fishman M, Finnerty J, Corbo J, Levine M, Leahy P, Davidson E, Ruvkun G. Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature 2000, 408: 86-89. PMID: 11081512, DOI: 10.1038/35040556.Peer-Reviewed Original ResearchConceptsLin-4Regulatory RNAsProtein-coding target genesLarval stagesAdult cell fateLin-4 RNASecond larval stageLate larval stagesAnimal phylogenyPoriferan speciesCaenorhabditis elegansRNA genesC. elegansSmall RNAsCell fateTemporal regulationTarget genesLate larvalLet-7Untranslated regionAdult stageTemporal expressionRNAEscherichia coliAnimal species