2021
Unfolded protein response triggers differential apoptotic mechanisms in ovaries and early embryos exposed to maternal type 1 diabetes
Okan A, Demir N, Sozen B. Unfolded protein response triggers differential apoptotic mechanisms in ovaries and early embryos exposed to maternal type 1 diabetes. Scientific Reports 2021, 11: 12759. PMID: 34140543, PMCID: PMC8211688, DOI: 10.1038/s41598-021-92093-3.Peer-Reviewed Original ResearchConceptsUnfolded protein responseProtein responseER stressDiabetes mellitusFemale mammalian reproductive systemEndoplasmic reticulum (ER)-stressMaternal type 1 diabetesEmbryonic developmentActivation of ER stressMammalian ovarian functionType 1 DMIn vivo mouse modelInduced developmental programAdult ovarian tissueEffect of DMMammalian reproductive systemEarly embryonic developmentEarly embryo developmentPre-implantation embryosType 1 diabetesApoptotic cascadeDiabetic ovariesMaternal DMActivated CHOPCaspase 12
2015
CD90 and CD105 expression in the mouse ovary and testis at different stages of postnatal development
Tepekoy F, Ozturk S, Sozen B, Ozay R, Akkoyunlu G, Demir N. CD90 and CD105 expression in the mouse ovary and testis at different stages of postnatal development. Reproductive Biology 2015, 15: 195-204. PMID: 26679159, DOI: 10.1016/j.repbio.2015.10.004.Peer-Reviewed Original ResearchConceptsExpression of CD90Postnatal developmentGerm cellsPostnatal dayCell typesSomatic cellsGerm cell compartmentMesenchymal stem cell markersStem cell markersStages of gonadal developmentStages of postnatal developmentExpression of CD105Female gonadal cellsMouse gonadsSertoli cellsPostnatal gonadsTesticular expressionMouse ovariesGonadal cellsCD105 expressionCell markersGonadal developmentAdult ovariesImmunohistochemical localizationCD105