Ultrastructural analysis of vascular features in cerebral cavernous malformations
Tanriover G, Sozen B, Seker A, Kilic T, Gunel M, Demir N. Ultrastructural analysis of vascular features in cerebral cavernous malformations. Clinical Neurology And Neurosurgery 2012, 115: 438-444. PMID: 22776801, DOI: 10.1016/j.clineuro.2012.06.023.Peer-Reviewed Original ResearchMeSH KeywordsApoptosis Regulatory ProteinsBlood VesselsBrainCarrier ProteinsCerebrovascular CirculationChromosome MappingEndothelium, VascularGene Expression RegulationHumansImmunohistochemistryIntracranial Arteriovenous MalformationsKRIT1 ProteinMembrane ProteinsMicroscopy, Electron, ScanningMicroscopy, Electron, TransmissionMicrotubule-Associated ProteinsNeurogliaPericytesPlatelet Endothelial Cell Adhesion Molecule-1Proto-Oncogene ProteinsStromal CellsConceptsCerebral cavernous malformationsVascular malformationsCavernous malformationsUltrastructural featuresBasal laminaIntact basal laminaHuman CCM lesionsConventional indicationsClinical behaviorThin vessel wallWeak immunostainingCCM lesionsVascular endotheliumPathogenic mechanismsLuminal endotheliumVascular featuresMalformationsEndothelial cellsEndotheliumVessel wallLesionsUltrastructural analysisIntercellular junctionsFirst studyRupture