Dehydroepiandrosterone supplementation attenuates ovarian ageing in a galactose-induced primary ovarian insufficiency rat model
Sozen B, Ozekinci M, Erman M, Gunduz T, Demir N, Akouri R. Dehydroepiandrosterone supplementation attenuates ovarian ageing in a galactose-induced primary ovarian insufficiency rat model. Journal Of Assisted Reproduction And Genetics 2019, 36: 2181-2189. PMID: 31422495, PMCID: PMC6823469, DOI: 10.1007/s10815-019-01560-4.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsDehydroepiandrosteroneDietary SupplementsDisease Models, AnimalFemaleGalactoseGalactosemiasHumansOvarian FolliclePregnancyPrimary Ovarian InsufficiencyRatsConceptsPrimary ovarian insufficiencyDehydroepiandrosterone treatmentOvarian agingDecreased follicle numberReduced follicle poolPrimordial follicle recruitmentGalactose-containing dietOvarian follicle countsEffect of dehydroepiandrosteroneExpression of Ki67 proteinBody weightApoptosis marker expressionExpression of cleaved-caspase-3MethodsPregnant ratsOffspring ovariesFollicle poolOvarian insufficiencyFollicle countCell death assessmentFollicle recruitmentOvarian tissueIncreased atresiaKi67 proteinRat modelGroup 2